Triple-negative tumors are characterized immunohistochemically by the absence of positivity to sex hormone receptors and to human epidermal growth factor receptor 2. Additionally, they are differentiated into basal-like and non-basal (or null) subtypes, based on the presence of basal cytokeratin expression (CK5/6, 14, and17). Triple-negative subtypes are yet to be characterized in male dogs, to our knowledge. We report herein the clinical and pathologic findings and molecular characterization of carcinoma in the mammary glands of 2 male dogs. Case 1 was diagnosed as a grade II tubulopapillary carcinoma; case 2 was diagnosed as a grade II carcinoma in a mixed tumor. The tumors were characterized phenotypically as triple-negative basal and triple-negative non-basal, respectively.

中文翻译：

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两只雄性狗中的三阴性乳腺癌。

三阴性肿瘤的特征是缺乏对性激素受体和人类表皮生长因子受体2阳性的免疫组织化学特征。此外，根据存在的基础，它们可分为基底样和非基底（或无效）亚型。细胞角蛋白表达（CK5 / 6、14和17）。据我们所知，三阴性亚型尚未在雄性狗中表征。我们在这里报告2雄狗的乳腺癌的临床和病理发现和分子表征。病例1被诊断为II级肾小管乳头状癌；病例2被诊断为混合肿瘤中的II级癌。在表型上将肿瘤分别表征为三阴性基底和三阴性非基底。