The course of viral diseases is accompanied by excessive generation of active oxygen metabolites, so the effectiveness of treatment can be improved by combining antiviral and antioxidant therapy. There was a screening of antioxidant properties of 6-nitro-1,2,4-triazoloazine-modified fragments of natural polyphenols (catechol, pyrogallol, phloroglucinol, resorcinol) which are potential dual-action combination preparations. Screening was carried out using various approaches: the study of redox transformations by cyclic voltammetry, determination of antioxidant capacity with oxidizing agents of a radical and non-radical nature by the potentiometric method using potassium hexacyanoferrate (III) and optical methods (the Folin assay and the DPPH assay). It has been established that molecules obtained by conjugation of polyphenols with heterocycles exhibit antioxidant properties. The exception is adducts of triazolodiazines with resorcinol. A decrease in the antioxidant ability of synthesized adducts relative to initial polyphenols has been noted. The antioxidant capacity has been studied at a number of temperatures (25 °C, 37 °C), and the reaction half-life has been determined. The correlation of antioxidant capacity by a potentiometric assay with the Folin assay was R = 0.71; by a potentiometric assay with the DPPH assay was R = 0.67. Leader compounds have been identified. Graphical abstract.

中文翻译：

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基于含有天然多酚片段的6-硝基-1,2,4-三唑嗪类药物的潜在材料的抗氧化剂筛选。

病毒性疾病的病程伴随着活性氧代谢产物的过量产生，因此可以通过结合抗病毒和抗氧化剂治疗来提高治疗效果。筛选了天然的多酚（邻苯二酚，邻苯三酚，间苯三酚，间苯二酚）的6-硝基-1,2,4-三唑并嗪改性的片段的抗氧化性能，它们是潜在的双重作用组合制剂。使用多种方法进行筛选：通过循环伏安法研究氧化还原转化，通过使用六氰合铁酸钾（III）的电位法和光学方法（Folin分析和DPPH分析）。已经确定，通过多酚与杂环的缀合获得的分子表现出抗氧化性能。三唑二嗪与间苯二酚的加合物除外。相对于初始多酚，已经注意到合成加合物的抗氧化能力降低。在许多温度（25°C，37°C）下研究了抗氧化能力，并确定了反应半衰期。电位测定法与Folin测定法的抗氧化能力的相关性为R = 0.71；通过电位测定法和DPPH测定法得到的R ＝ 0.67。前导化合物已被鉴定。图形概要。在许多温度（25°C，37°C）下研究了抗氧化能力，并确定了反应半衰期。电位测定法与Folin测定法的抗氧化能力相关性为R = 0.71；通过电位测定法和DPPH测定法得到的R ＝ 0.67。前导化合物已被鉴定。图形概要。在许多温度（25°C，37°C）下研究了抗氧化能力，并确定了反应半衰期。电位测定法与Folin测定法的抗氧化能力相关性为R = 0.71；通过电位测定法和DPPH测定法得到的R ＝ 0.67。前导化合物已被鉴定。图形概要。