Introduction: Thymoquinone (TQ), 2-isopropyl-5-methylbenzo-1, 4-quinone, the main active constituent of Nigella sativa (NS) plant, has been proven to be of great therapeutic aid in various in vitro and in vivo conditions. Despite the promising therapeutic activities of TQ, this molecule is not yet in the clinical trials, restricted by its poor biopharmaceutical properties including photo-instability.Area covered: This review compiles the different types of polymeric and lipidic nanocarriers (NCs), encapsulating TQ for their improved oral bioavailability, and augmented in vitro and in vivo efficacy, evidenced on various pathologies. Furthermore, we provide a comprehensive overview of TQ in relation to its encapsulation approaches advancing the delivery and improving the efficacy of TQ.Expert opinion: TQ was first identified in the essential oil of Nigella sativa L. black seed. TQ has not been used in formulations because it is a highly hydrophobic drug having poor aqueous solubility. To deal with the poor physicochemical problems associated with TQ, various NCs encapsulating TQ have been tried in the past. Nevertheless, these NCs could be impending in bringing forth this potential molecule to clinical reality. This will also be beneficial for a large research community including pharmaceutical & biological sciences and translational researchers.

中文翻译：

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纳米载体：比胸腺醌更胜一筹。

简介：百里香（NS）植物的主要活性成分胸腺嘧啶（TQ），2-异丙基-5-甲基苯并-1、4-醌已被证明在各种体外和体内条件下均具有巨大的治疗辅助作用。尽管TQ的治疗活性令人鼓舞，但由于其不良的生物药物特性（包括光不稳定性），该分子尚未进入临床试验。研究范围：本综述汇编了不同类型的聚合物和脂质纳米载体（NCs），将TQ封装为它们在各种病理学上都有改善的口服生物利用度，并提高了体外和体内功效。此外，我们就TQ的封装方法提供了全面的概述，这些封装方法可促进TQ的交付并提高TQ的效力。专家意见：TQ最先在黑黑黑种子种子精油中鉴定。TQ尚未用于制剂中，因为它是水溶性很差的高疏水性药物。为了解决与TQ相关的较差的理化问题，过去曾尝试过各种封装TQ的NC。然而，这些NCs可能正试图将这种潜在分子带入临床。这对于包括制药和生物科学以及转化研究人员在内的大型研究社区也将是有益的。这些NCs可能正将这种潜在分子带入临床。这对于包括制药和生物科学以及转化研究人员在内的大型研究社区也将是有益的。这些NCs可能正将这种潜在分子带入临床。这对于包括制药和生物科学以及转化研究人员在内的大型研究社区也将是有益的。