Multidrug-Resistant Escherichia coli Strain Isolated from Swine in China Harbors mcr-3.1 on a Plasmid of the IncX1 Type That Cotransfers with mcr-1.1.,Foodborne Pathogens and Disease

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Multidrug-Resistant Escherichia coli Strain Isolated from Swine in China Harbors mcr-3.1 on a Plasmid of the IncX1 Type That Cotransfers with mcr-1.1.
Foodborne Pathogens and Disease ( IF 2.8 ) Pub Date : 2020-10-06 , DOI: 10.1089/fpd.2019.2769
Dewei Sun _{1,

2} , Shanshan Jin _{1,

2} , Jing Wang _{1,

2} , Zhenyu Wang _{1,

2} , Jiajian Fan _{1,

2} , Zhengzhong Xu _{1,

2} , Yaohui Xu ₃ , Xiang Chen _{1,

2} , Xin'an Jiao _{1,

2}

Affiliation

An Escherichia coli strain isolated from the feces of swine at a pork slaughterhouse in Henan province China was found to possess two colistin-resistance genes, mcr-1 and mcr-3, plus 16 additional resistance genes. Genes mcr-1.1 and mcr-3.1 were identified on IncHI2 and IncX1 type plasmids, respectively. Transconjugants (containing mcr-3, mcr-1&mcr-3) were obtained that were 64- and 512-fold higher than the minimum inhibitory concentration of colistin on the recipient bacteria (E. coli C600), respectively. The IncX1 plasmid containing mcr-3.1 displayed a very specific structure compared with previous mcr-3. Variable and stable regions were similar across different plasmids, multiple insertion sequences and transposases.

更新日期：2020-10-11

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