Polycystic ovary syndrome (PCOS) is one of the most common female reproductive metabolisms. It is an endocrine disease that affects reproductive women and often exhibits with hyperandrogenemia, insulin resistance (IR), low inflammation, and an increased risk of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular events such as hypertension and dyslipidemia in patients. However, the molecular mechanism of PCOS is still unclear. Recently, an increasing number of studies have shown that the oxidative stress induced by mitochondrial dysfunction has negative effects on IR, lipid metabolism, and follicular development, suggesting that mitochondrial dysfunction plays an essential role in the development of PCOS. Abnormal mitochondrial DNA copy number in patients with PCOS, and mitochondrial gene mutations, has been the focus of research in recent years, and functional mitochondrial diseases have been gradually accepted as a related factor in PCOS. This review is intended to summarize and discuss previous and recent studies and findings on the connections between mitochondrial dysfunction and PCOS.

中文翻译：

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多囊卵巢综合征的线粒体功能障碍。

多囊卵巢综合征（PCOS）是最常见的女性生殖代谢之一。它是一种影响生殖妇女的内分泌疾病，通常表现为高雄激素血症，胰岛素抵抗（IR），低炎症，并增加了2型糖尿病，代谢综合征和心血管事件（例如患者的高血压和血脂异常）的风险。但是，PCOS的分子机制仍不清楚。最近，越来越多的研究表明，线粒体功能障碍引起的氧化应激对IR，脂质代谢和卵泡发育具有负面影响，这表明线粒体功能障碍在PCOS的发展中起重要作用。PCOS患者的线粒体DNA拷贝数异常，以及线粒体基因突变，近年来，一直以来，功能性线粒体疾病已成为PCOS的相关因素。这篇综述旨在总结和讨论以前和最近关于线粒体功能障碍与PCOS之间联系的研究和发现。