Abstract

Human endothelial cells-derived polyphosphate (PolyP) is one of the pro-inflammatory mediators as suggested by the previous reports. Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. Aloin inhibits PolyP-mediated barrier disruption, the expressions of cell adhesion molecules, and adhesion/migration of leukocyte to HUVEC. PolyP-induced NF-κB activation and the productions of TNF-α and IL-6 were inhibited by aloin in HUVECs. These anti-inflammatory functions of aloin were confirmed in PolyP-injected mice. In conclusion, based on the anti-inflammatory effects of aloin in PolyP-mediated septic response, aloin has therapeutic potential for various systemic inflammatory diseases.

摘要

如先前报道所建议，人内皮细胞衍生的多磷酸盐（PolyP）是促炎性介质之一。芦荟素是从芦荟种获得的主要蒽醌糖苷，并表现出抗炎和抗氧化活性。Aloin抑制PolyP介导的屏障破坏，细胞粘附分子的表达以及白细胞向HUVEC的粘附/迁移。芦荟素抑制了HUVECs中PolyP诱导的NF-κB活化以及TNF-α和IL-6的产生。在注射了PolyP的小鼠中证实了芦荟蛋白的这些抗炎功能。总之，基于芦荟蛋白在PolyP介导的败血症反应中的抗炎作用，芦荟素对多种全身性炎症性疾病具有治疗潜力。