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The Glial Perspective on Sleep and Circadian Rhythms.
Annual Review of Neuroscience ( IF 12.1 ) Pub Date : 2020-07-08 , DOI: 10.1146/annurev-neuro-091819-094557
Gregory Artiushin 1 , Amita Sehgal 1
Affiliation  

While neurons and circuits are almost unequivocally considered to be the computational units and actuators of behavior, a complete understanding of the nervous system must incorporate glial cells. Far beyond a copious but passive substrate, glial influence is inextricable from neuronal physiology, whether during developmental guidance and synaptic shaping or through the trophic support, neurotransmitter and ion homeostasis, cytokine signaling and immune function, and debris engulfment contributions that this class provides throughout an organism's life. With such essential functions, among a growing literature of nuanced roles, it follows that glia are consequential to behavior in adult animals, with novel genetic tools allowing for the investigation of these phenomena in living organisms. We discuss here the relevance of glia for maintaining circadian rhythms and also for serving functions of sleep.

中文翻译:



神经胶质对睡眠和昼夜节律的看法。



虽然神经元和电路几乎被明确地认为是计算单元和行为执行器,但对神经系统的完整理解必须包含神经胶质细胞。胶质细胞的影响远远超出了丰富但被动的底物,它与神经生理学密不可分,无论是在发育指导和突触塑造过程中,还是通过此类在整个过程中提供的营养支持、神经递质和离子稳态、细胞因子信号传导和免疫功能以及碎片吞噬贡献。有机体的生命。凭借这些基本功能,在越来越多的关于微妙作用的文献中,可以得出结论,神经胶质细胞对成年动物的行为至关重要,而新的遗传工具允许在活体生物体中研究这些现象。我们在这里讨论神经胶质细胞与维持昼夜节律和服务睡眠功能的相关性。

更新日期:2020-07-09
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