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Neural Mechanisms of Itch.
Annual Review of Neuroscience ( IF 12.1 ) Pub Date : 2020-07-08 , DOI: 10.1146/annurev-neuro-083019-024537
Mark Lay 1 , Xinzhong Dong 1, 2
Affiliation  

Itch is a unique sensation that helps organisms scratch away external threats; scratching itself induces an immune response that can contribute to more itchiness. Itch is induced chemically in the peripheral nervous system via a wide array of receptors. Given the superficial localization of itch neuron terminals, cells that dwell close to the skin contribute significantly to itch. Certain mechanical stimuli mediated by recently discovered circuits also contribute to the itch sensation. Ultimately, in the spinal cord, and likely in the brain, circuits that mediate touch, pain, and itch engage in cross modulation. Much of itch perception is still a mystery, but we present in this review the known ligands and receptors associated with itch. We also describe experiments and findings from investigations into the spinal and supraspinal circuitry responsible for the sensation of itch.

中文翻译:


痒的神经机制。

痒是一种独特的感觉,可以帮助生物体摆脱外部威胁;抓挠本身会诱发免疫反应,导致更痒。外周神经系统通过多种受体化学诱导瘙痒。鉴于瘙痒神经元末梢的表面定位,靠近皮肤的细胞对瘙痒有显着影响。最近发现的电路介导的某些机械刺激也会导致瘙痒感。最终,在脊髓中,也可能在大脑中,介导触觉、疼痛和瘙痒的回路参与交叉调制。大部分痒感仍然是个谜,但我们在这篇综述中介绍了与痒感相关的已知配体和受体。

更新日期:2020-07-09
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