INTRODUCTION Hypopituitary patients are at risk for bone loss. Hypothalamic-posterior pituitary hormones oxytocin and vasopressin are anabolic and catabolic, respectively, to the skeleton. Patients with hypopituitarism may be at risk for oxytocin deficiency. Whether oxytocin and/or vasopressin contribute to impaired bone homeostasis in hypopituitarism is unknown. OBJECTIVES To determine the relationship between plasma oxytocin and vasopressin levels and bone characteristics (bone mineral density [BMD] and hip structural analysis [HSA]) in patients who have anterior pituitary deficiencies only (APD group) or with central diabetes insipidus (CDI group). METHODS This is a cross-sectional study. Subjects included 37 men (17 CDI and 20 APD), aged 20-60 years. Main outcome measures were fasting plasma oxytocin and vasopressin levels, and BMD and HSA using dual X-ray absorptiometry. RESULTS Mean BMD and HSA variables did not differ between the CDI and APD groups. Mean BMD Z-scores at most sites were lower in those participants who had fasting oxytocin levels below, rather than above, the median. There were positive associations between fasting oxytocin levels and (1) BMD Z-scores at the spine, femoral neck, total hip, and subtotal body and (2) favorable hip geometry and strength variables at the intertrochanteric region in CDI, but not APD, participants. No associations between vasopressin levels and bone variables were observed in the CDI or ADP groups. CONCLUSIONS This study provides evidence for a relationship between oxytocin levels and BMD and estimated hip geometry and strength in hypopituitarism with CDI. Future studies will be important to determine whether oxytocin could be used therapeutically to optimize bone health in patients with hypopituitarism.

中文翻译：

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较低的催产素水平与低垂体男性的较低骨矿物质密度和不太有利的髋部几何形状有关。

引言 垂体功能低下的患者有骨质流失的风险。下丘脑-垂体后叶激素催产素和加压素分别对骨骼具有合成代谢和分解代谢作用。垂体功能低下的患者可能存在催产素缺乏的风险。催产素和/或加压素是否会导致垂体功能减退的骨稳态受损尚不清楚。目的 确定仅有垂体前叶缺陷（APD 组）或中枢性尿崩症（CDI 组）的患者血浆催产素和加压素水平与骨特征（骨矿物质密度 [BMD] 和髋关节结构分析 [HSA]）之间的关系. 方法 这是一项横断面研究。受试者包括 37 名男性（17 名 CDI 和 20 名 APD），年龄在 20-60 岁之间。主要结果测量是空腹血浆催产素和加压素水平，和 BMD 和 HSA 使用双 X 射线吸收测定法。结果平均 BMD 和 HSA 变量在 CDI 和 APD 组之间没有差异。大多数部位的平均 BMD Z 分数在那些空腹催产素水平低于而不是高于中位数的参与者中较低。空腹催产素水平与 (1) 脊柱、股骨颈、全髋和小体的 BMD Z 评分和 (2) CDI 中转子间区域有利的髋部几何形状和力量变量之间存在正相关，但与 APD 无关，参与者。在 CDI 或 ADP 组中未观察到加压素水平与骨骼变量之间的关联。结论 本研究提供了催产素水平与 BMD 之间关系的证据，以及 CDI 垂体功能减退患者髋部几何形状和力量的估计值。