BACKGROUND Data on female fertility, pregnancy, and outcome of offspring after childhood-onset craniopharyngioma (CP) are rare. STUDY DESIGN Observational study on pregnancy rate and offspring outcome in female CP patients recruited in KRANIOPHARYNGEOM 2000/2007 since 2000. RESULTS A total of 451 CP patients (223 female) have been recruited, and 269 (133 female) were postpubertal at study. Six of 133 female CP patients (4.5%) with a median age of 14.9 years at CP diagnosis had 9 pregnancies, giving birth to 10 newborns. Three patients achieved complete surgical resections. No patient underwent postoperative irradiation. Five natural pregnancies occurred in 3 CP patients without pituitary deficiencies. Four pregnancies in 3 CP patients with hypopituitarism were achieved under assisted reproductive techniques (ART) (median 4.5 cycles, range: 3-6 cycles). Median maternal age at pregnancy was 30 years (range: 22-41 years). Six babies (60%) were delivered by caesarean section. Median gestational age at delivery was 38 weeks (range: 34-43 weeks); median birth weight was 2,920 g (range: 2,270-3,520 g), the rate of preterm delivery was 33%. Enlargements of CP cysts occurred in 2 women during pregnancy. Other complications during pregnancy, delivery, and postnatal period were not observed. CONCLUSIONS Pregnancies after CP are rare and were only achieved after ART in patients with hypopituitarism. Close monitoring by an experienced reproductive physician is necessary. Due to a potentially increased risk for cystic enlargement, clinical, ophthalmological, and MRI monitoring are recommended in patients at risk. Severe perinatal complications, birth defects, and postnatal morbidity of mothers and offspring were not observed.

中文翻译：

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儿童颅咽管瘤后妊娠：KRANIOPHARYNGEOM 2000/2007 的结果和文献综述。

背景 关于儿童期发病的颅咽管瘤 (CP) 后女性生育能力、妊娠和后代结局的数据很少。研究设计 自 2000 年以来在 KRANIOPHARYNGEOM 2000/2007 招募的女性 CP 患者的妊娠率和后代结局的观察性研究。结果 总共招募了 451 名 CP 患者（223 名女性），269 名（133 名女性）在研究中处于青春期后。133 名女性 CP 患者中有 6 名 (4.5%) 在 CP 诊断时的中位年龄为 14.9 岁，怀孕 9 次，生了 10 个新生儿。三名患者实现了完全手术切除。没有患者接受术后放疗。3 名无垂体缺陷的 CP 患者发生了 5 次自然妊娠。3 名垂体功能减退症 CP 患者在辅助生殖技术 (ART) 下怀孕 4 次（中位数 4.5 个周期，范围：3-6 个循环）。孕产妇年龄中位数为 30 岁（范围：22-41 岁）。六名婴儿 (60%) 是通过剖腹产分娩的。分娩时的中位胎龄为 38 周（范围：34-43 周）；出生体重中位数为 2,920 克（范围：2,270-3,520 克），早产率为 33%。2 名妇女在怀孕期间出现 CP 囊肿增大。未观察到妊娠、分娩和产后期间的其他并发症。结论 CP 后怀孕是罕见的，只有在垂体功能减退症患者接受 ART 后才能怀孕。有必要由经验丰富的生殖医生进行密切监测。由于囊肿增大的潜在风险增加，建议有风险的患者进行临床、眼科和 MRI 监测。严重的围产期并发症、出生缺陷、