Antimicrobials have been known for millennia, but innovative antibiotics are currently in short supply. New antimicrobial discoveries are being threatened by planetary scale loss of biodiversity that has important impacts on species and ecosystems. This expert review underscores that microorganisms in nature and their diversity are essential cornerstones to revitalize the antibiotic innovation and discovery pipeline. The recent rise of systems ecology and planetary health offers new and actionable potentials in this regard. Without a systems scale focus and appreciation of systems ecology, the global threats to human and planetary health from inappropriate use of antibiotics and antimicrobial resistance will continue to escalate with serious consequences to all life on the planet. With acutely pressing research and development needs to revitalize antibiotic treatment and novel diagnostic tools for personalized medicine, national health systems ought to work across knowledge silos not only within but also across the ministries, for example, health, agriculture, environment, economy, trade, and social services ministries that collectively impact on systems ecology and by extension on health innovations including the antibiotic discovery pipeline. Such systems vision can also help to revitalize antibiotic discovery pipeline as most antibiotics have natural origins or have designs inspired or based on molecules in the environment and microorganisms that produce antibiotics. Above all, our audience and responsibility include every person who has an interest in his or her own health, in the health of his or her fellow human beings and all life on the planet, and in the health of future generations.

中文翻译：

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现在是振兴抗生素管道的时候了：系统生态学可以帮助您。

抗菌素已经有数千年的历史了，但是目前缺乏创新的抗菌素。新的抗菌发现正受到生物多样性在全球范围内流失的威胁，这对物种和生态系统具有重要影响。该专家评论强调，自然界中的微生物及其多样性是振兴抗生素创新和发现渠道的重要基石。系统生态学和行星健康的最新兴起在这方面提供了新的可操作的潜力。没有系统规模的关注和对系统生态的重视，不当使用抗生素和抗微生物剂对人类和行星健康的全球威胁将继续升级，对地球上的所有生命造成严重后果。随着迫切的研发需求，需要振兴抗生素治疗和新颖的个性化医学诊断工具，国家卫生系统不仅应跨部门，而且应跨部委（例如卫生，农业，环境，经济，贸易，和社会服务部，这些部门共同影响系统生态，并扩展到包括抗生素发现管道在内的健康创新领域。这种系统的视野还可以帮助振兴抗生素的发现渠道，因为大多数抗生素是自然起源的，或者具有受启发或基于环境中的分子和产生抗生素的微生物的设计。最重要的是，我们的听众和责任包括每个对自己的健康感兴趣的人，