After graduating as a medical doctor with summa cum laude in 2015 from Semmelweis University, Budapest, Hungary I went on to purse a PhD degree in clinical medicine under the supervision of Dr. Agnes Jermendy. Currently, I am a PhD candidate and a Pediatric Resident at the 1st Department of Pediatrics, Semmelweis University. Since medical school I have a special interest in therapy optimization of children who were born with neonatal encephalopathy (NE), which affects 1–3 infants per 1000 full-term live births in developed countries and related to one-quarter of the 4 million annual neonatal deaths worldwide. I have been moved by the countless cases that I saw in the past 6 years during my clinical research. The magnitude of the problem is clear from both a personal and an economic perspective and my ultimate goal is to find early intervention procedures, available already in the neonatal period, rather than let these children face belated rehabilitation efforts in the adulthood. Adjunctive pharmacological agents have been heavily investigated over the last decades; however, the optimization of the intensive care including monitoring techniques may be a reasonable approach to improve long-term outcomes in infants with NE. The HENRIC trial was an investigator initiated clinical trial with the aim to test the safety and feasibility of adding carbon dioxide to the inhaled gas mixture in low concentration to correct hypocapnia in infants underwent therapeutic hypothermia. These kinds of studies are rare in neonatology due to their complexity; however, the findings of such trials cloud have a great impact on the clinical care of infants in the future. During my PhD studies I have been really fortunate to work with very knowledgeable and highly dedicated clinicians and researchers, many of whom are coauthors on the paper of the HENRIC trial. In addition, I also had the opportunity to spend a considerable time abroad that broadened my horizons. A short fellowship at Cambridge University Hospital enabled me to learn about the advanced respiratory management in neonatal intensive care. I also spent one year at the Department of Pediatric Newborn Medicine in Brigham and Women’s Hospital, Boston as a postdoctoral research fellow. I have been honored to work under the mentorship of Dr. Mohamed El-Dib focusing on the neurocritical care of newborns. I strongly believe that a medical doctor should combine the regular clinical work with research and teaching activities to provide the best care for patients and to facilitate scientific and therapeutic advances.

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2020 年 5 月 ECI 生物评论

在 2015 年以优异成绩从匈牙利布达佩斯塞梅维什大学毕业后，我继续在 Agnes Jermendy 博士的指导下攻读临床医学博士学位。目前，我是塞梅维什大学第一儿科系的博士生和儿科住院医师。自医学院以来，我对新生儿脑病 (NE) 儿童的治疗优化特别感兴趣，这在发达国家每 1000 名足月活产中影响 1-3 名婴儿，并且与每年 400 万例中的四分之一有关全球新生儿死亡人数。过去6年在临床研究中看到的无数案例让我感动。从个人和经济的角度来看，问题的严重性是显而易见的，我的最终目标是找到早期干预程序，在新生儿期就已经可用，而不是让这些孩子在成年后面临迟来的康复工作。在过去的几十年里，对辅助药物进行了大量研究。然而，包括监测技术在内的重症监护的优化可能是改善 NE 婴儿长期预后的合理方法。HENRIC 试验是研究人员发起的临床试验，目的是测试向吸入气体混合物中添加低浓度二氧化碳以纠正接受治疗性低温的婴儿的低碳酸血症的安全性和可行性。由于其复杂性，这些类型的研究在新生儿学中很少见。然而，此类试验云的结果对未来婴儿的临床护理有很大的影响。在我的博士研究期间，我真的很幸运能与知识渊博且高度敬业的临床医生和研究人员一起工作，其中许多人是 HENRIC 试验论文的合著者。此外，我也有机会在国外度过了相当长的一段时间，开阔了我的视野。在剑桥大学医院的短期奖学金使我了解了新生儿重症监护中的高级呼吸管理。我还在波士顿布莱根妇女医院的儿科新生儿医学系做了一年博士后研究员。我很荣幸在 Mohamed El-Dib 博士的指导下工作，专注于新生儿的神经重症监护。