Introduction: Fracture-related infection (FRI) is a serious complication related to orthopedic trauma, both from an infectious disease and a surgical point of view. The lack of scientific data with respect to diagnostic criteria and treatment principles of this entity has hampered efforts for an evidence-based approach and, as such, practices to prevent and treat FRI are often extrapolated from peri-prosthetic joint infection (PJI) literature. Recently, consensus guidelines were developed with respect to prevention, diagnosis and treatment of FRI.Areas covered: This review will define FRI and approaches to prevent and treat this complication will be discussed, with an emphasis on antimicrobial and surgical considerations. Guidelines focusing on FRI will be highlighted and aspects of pre-clinical research with imminent translational potential described.Expert opinion: New strategies are currently under investigation to improve the outcome of this sometimes-devastating complication. Local delivery of antimicrobials seems to be a promising approach; however, further high-quality clinical research is necessary to demonstrate efficacy. Delivery mechanisms for local antimicrobials include polymethyl methacrylate, implant coatings, collagen fleece, hydrogels and ceramics. The reintroduction of antimicrobials such as bacteriophage therapy has demonstrated promise in the management of drug-resistant organisms.

中文翻译：

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骨折相关感染：目前的预防和治疗方法。

简介：从传染病和外科角度来看，骨折相关感染（FRI）是与骨科创伤相关的严重并发症。缺乏有关该实体诊断标准和治疗原则的科学数据，阻碍了基于证据的方法的努力，因此，预防和治疗FRI的方法通常是从假体周围关节感染（PJI）文献中推断出来的。最近，就FRI的预防，诊断和治疗制定了共识性指南。涉及的领域：本综述将定义FRI，并讨论预防和治疗这种并发症的方法，重点是抗菌和手术方面的考虑。将重点介绍针对FRI的指南，并描述具有潜在翻译潜力的临床前研究方面。专家意见：目前正在研究新的策略，以改善这种有时毁灭性并发症的结果。局部递送抗菌药物似乎是一种有前途的方法。然而，进一步的高质量临床研究对于证明疗效是必要的。局部抗菌剂的递送机制包括聚甲基丙烯酸甲酯，植入物涂层，胶原绒，水凝胶和陶瓷。诸如细菌噬菌体疗法等抗菌药物的重新引入已证明在耐药生物的管理中具有前景。局部递送抗菌药物似乎是一种有前途的方法。然而，进一步的高质量临床研究对于证明疗效是必要的。局部抗菌剂的递送机制包括聚甲基丙烯酸甲酯，植入物涂层，胶原绒，水凝胶和陶瓷。诸如细菌噬菌体疗法之类的抗菌剂的重新引入在耐药菌的管理中显示出了希望。局部递送抗菌药物似乎是一种有前途的方法。然而，进一步的高质量临床研究对于证明疗效是必要的。局部抗菌剂的递送机制包括聚甲基丙烯酸甲酯，植入物涂层，胶原绒，水凝胶和陶瓷。诸如细菌噬菌体疗法等抗菌药物的重新引入已证明在耐药生物的管理中具有前景。