Aim: To analyze the impact of CD32a polymorphism rs1801274 on the occurrence of Kawasaki disease (KD) through the meta-analysis.Methods: The correlation between CD32a polymorphism rs1801274 and the susceptibility to KD was appraised using summarized odds ratios (ORs) with their 95% confidence intervals (95% CIs). Besides, stratification analyses were further implemented on the basis of ethnicity and control source, respectively. Between-study heterogeneity was checked adopting chi-square-based Q test, with p < .05 as significant level. And results from Q test determined which model would be employed for OR calculation, fixed- or random-effects. Sensitivity analysis was accomplished to test the stability of final results. Potential publication bias among included studies was investigated using Begg's funnel plot and Egger's test. If publication bias was significant, its influence on overall estimates would be measured adopting the trim-and-fill method.Results: CD32a polymorphism rs1801274 significantly increased KD risk in total analysis under the comparisons of AA vs. GG, AA + AG vs. GG, AA vs. GG + AG, A vs. G and AG vs. GG (OR = 2.69, 95% CI = 1.39-5.20; OR = 2.00, 95% CI = 1.23-3.26; OR = 1.90, 95% CI = 1.23-2.94; OR = 1.77, 95% CI = 1.34-2.34; OR = 1.53, 95% CI = 1.07-2.19). After stratification analysis by ethnicity, similar tendency was also observed in Caucasian and Asian subgroups under corresponding genetic models. And parallel results were replicated in population-based and other-source subgroups after stratified analysis by control source, under some contrasts.Conclusion: CD32a polymorphism rs1801274 has strong relation to KD onset, and the presence of its A allele could elevate the disease incidence.

中文翻译：

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CD32a多态性rs1801274影响川崎病的风险。

目的：通过荟萃分析，分析CD32a多态性rs1801274对川崎病（KD）发生的影响。方法：采用汇总比值比（OR）和95分法评估CD32a多态性rs1801274与KD易感性之间的相关性。置信区间百分比（95％CI）。此外，在族裔和控制来源的基础上分别进行了分层分析。研究之间的异质性采用基于卡方的Q检验进行了检验，其中p <.05为显着水平。Q测试的结果确定了将使用哪种模型进行OR计算，固定效应或随机效应。进行灵敏度分析以测试最终结果的稳定性。使用Begg的漏斗图和Egger检验研究了纳入研究中潜在的出版偏倚。如果发表偏倚显着，则将采用修整和填充方法来衡量其对总体估计的影响。结果：在AA与GG，AA + AG与GG的比较中，CD32a多态性rs1801274在总分析中显着增加了KD风险。 ，AA与GG + AG，A与G和AG与GG（或= 2.69，95％CI = 1.39-5.20；或= 2.00，95％CI = 1.23-3.26；或= 1.90，95％CI = 1.23-2.94； OR = 1.77，95％CI = 1.34-2.34； OR = 1.53，95％CI = 1.07-2.19）。通过种族分层分析后，在相应的遗传模型下，在白种人和亚洲亚组中也观察到了类似的趋势。并通过对照来源进行分层分析后，在基于人群的亚群和其他来源的亚组中重复了平行结果。结论：CD32a多态性rs1801274与KD发作密切相关，