Algal Oil Containing EPA and DHA (AOCED) at approximately 50% was developed as a sustainable n−3 fatty acid source. AOCED was incorporated in diets at dose levels of 0%, 0.75%, 1.5% and 3.0% (w/w) and administered to healthy domestic shorthair female cats starting two weeks before mating, then during mating, gestation, lactation and to their kittens until they reached 32 weeks of age. The diets were made isocaloric and met the Association of American Feed Control Officials (AAFCO) nutrient requirements of cats for growth and reproduction. Dietary AOCED treatment did not affect the overall health, physiological parameters, food consumption and body weights of the queens and their kittens. No AOCED‐related changes in haematology, coagulation or clinical chemistry parameters were observed in either generation when compared to control cats. Plasma levels of EPA and DHA were dose‐dependently increased in both generations, demonstrating bioavailability of the fatty acids. In this study, safety of AOCED at levels up to 3.0% in the diet was demonstrated in cats with administration starting in utero and until kittens reached 32 weeks of age. Bioavailability of EPA and DHA in cats supports use of AOCED as a source of EPA and DHA for feline growth and reproduction.

中文翻译：

---

在妊娠，哺乳和生长期间，含有EPA和DHA的藻油对猫的安全性。

含有大约50％的EPA和DHA（AOCED）的藻油被开发为可持续的n-3脂肪酸来源。将AOCED以0％，0.75％，1.5％和3.0％（w / w）的剂量添加到饮食中，并在交配前两周开始，然后在交配，妊娠，哺乳及其小猫中，向健康的家养短毛猫母猫给药直到他们达到32周龄。这些饮食是等热量的，并且满足了猫生长和繁殖所必需的美国饲料控制官员协会（AAFCO）的营养要求。膳食AOCED处理不会影响皇后区及其小猫的整体健康，生理参数，食物消耗和体重。与对照猫相比，两代均未观察到AOCED相关的血液学，凝血或临床化学参数变化。EPA和DHA的血浆水平在两代中均呈剂量依赖性增加，表明脂肪酸的生物利用度。在这项研究中，从子宫内开始给药直至猫达到32周龄为止，猫中饮食中AOCED的安全性最高达到3.0％。猫中EPA和DHA的生物利用度支持将AOCED用作猫生长和繁殖的EPA和DHA的来源。