Brain tumour diagnostics using a DNA methylation‐based classifier as a diagnostic support tool,Neuropathology and Applied Neurobiology

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Brain tumour diagnostics using a DNA methylation‐based classifier as a diagnostic support tool
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2020-04-07 , DOI: 10.1111/nan.12610
L P Priesterbach-Ackley ₁ , H B Boldt _{2,

3} , J K Petersen _{2,

3} , N Bervoets ₁ , D Scheie ₄ , B P Ulhøi ₅ , M Gardberg ₆ , T Brännström ₇ , S H Torp ₈ , E Aronica ₉ , B Küsters ₁₀ , W F A den Dunnen ₁₁ , F Y F L de Vos ₁₂ , P Wesseling _{13,

14} , W W J de Leng ₁ , B W Kristensen _{2,

3}

Affiliation

Department of Pathology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Department of Pathology, Odense University Hospital, Odense, Denmark.
Research Unit of Pathology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
Department of Pathology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland.
Department of Pathology, Norrlands University Hospital, Umeå, Sweden.
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Department of Neuropathology, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Pathology, University Medical Centre Groningen, Groningen, The Netherlands.
Department of Medical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands.
Department of Pathology, Amsterdam University Medical Centres/VU Medical Centre, Amsterdam, The Netherlands.

Methylation profiling (MP) is increasingly incorporated in the diagnostic process of central nervous system (CNS) tumours at our centres in The Netherlands and Scandinavia. We aimed to identify the benefits and challenges of MP as a support tool for CNS tumour diagnostics.

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