Mutations in the genes of the renin-angiotensin system result in congenital anomalies of the kidney and urinary tract (CAKUT), the main cause of end-stage renal disease in children. The molecular mechanisms that cause CAKUT are unclear in most cases. To improve the care of children with CAKUT, it is critical to determine the underlying mechanisms of CAKUT. In this review, we discuss recent advances that have helped to better understand how disruption of the renin-angiotensin system during kidney development contributes to CAKUT.

中文翻译：

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哺乳动物肾脏发育中的肾素-血管紧张素系统。

肾素-血管紧张素系统基因突变导致肾脏和泌尿道先天性异常 (CAKUT)，这是儿童终末期肾病的主要原因。在大多数情况下，导致 CAKUT 的分子机制尚不清楚。为了改善 CAKUT 儿童的护理，确定 CAKUT 的潜在机制至关重要。在这篇综述中，我们讨论了最近的进展，这些进展有助于更好地了解肾脏发育过程中肾素-血管紧张素系统的破坏如何导致 CAKUT。