The study of Roy and colleagues recently accepted for publication in International Journal of Neuropsychopharmacology is a very interesting report investigating the role of specific microRNAs (miRNAs) in vulnerability or resistance to major depressive disorder in a specific brain region (e.g., amygdala). MiRNAs may act as a mega-controller of gene expression being involved in the pathogenesis of major neuropsychiatric conditions. Interestingly, some of the altered miRNAs (e.g., hsa-miR-425-3p, miR-425, miR-674-3p, and miR-873-3p) identified in this study were found to be dysregulated even in existing studies, but several methodological issues may hamper the translation of basic research findings in clinical studies. MiRNAs are proposed as possible biomarkers of disease and treatment response to disentangle the biological complexity underlying major affective disorders. The main implications regarding the present findings are discussed.

中文翻译：

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关于Roy等人研究的评论。基于杏仁核的mir-128-3p改变，通过Wnt信号传递给抑郁症样行为的易感性。

Roy及其同事最近在《国际神经心理药理学杂志》上接受发表的研究是一项非常有趣的报告，研究了特定microRNA（miRNA）在特定大脑区域（例如杏仁核）对主要抑郁症的抵抗力或抵抗力中的作用。MiRNA可能充当基因表达的大型控制器，参与主要神经精神疾病的发病机制。有趣的是，即使在现有研究中，也发现在这项研究中鉴定出的某些改变的miRNA（例如hsa-miR-425-3p，miR-425，miR-674-3p和miR-873-3p）失调，但是几个方法学问题可能会妨碍临床研究中基础研究结果的翻译。提出了miRNAs作为疾病和治疗反应的可能生物标志物，以消除主要情感障碍的生物学复杂性。讨论了有关本研究结果的主要含义。