Cardiac neural crest (CNC) cells are pluripotent cells derived from the dorsal neural tube that migrate and contribute to the remodeling of pharyngeal arch arteries and septation of the cardiac outflow tract (OFT). Numerous molecular cascades regulate the induction, specification, delamination, and migration of the CNC. Extensive analyses of the CNC ranging from chick ablation models to molecular biology studies have explored the mechanisms of heart development and disease, particularly involving the OFT and aortic arch (AA) system. Recent studies focus more on reciprocal signaling between the CNC and cells originated from the second heart field (SHF), which are essential for the development of the OFT myocardium, providing new insights into the molecular mechanisms underlying congenital heart diseases (CHDs) and some human syndromes.

中文翻译：

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 心脏神经嵴。


心脏神经嵴 (CNC) 细胞是源自背神经管的多能细胞，可迁移并有助于咽弓动脉的重塑和心脏流出道 (OFT) 的分隔。许多分子级联调节 CNC 的诱导、规范、分层和迁移。对 CNC 的广泛分析，从雏鸡消融模型到分子生物学研究，探索了心脏发育和疾病的机制，特别是涉及 OFT 和主动脉弓 (AA) 系统。最近的研究更多地关注 CNC 和源自第二心脏区域 (SHF) 的细胞之间的相互信号传导，这对于 OFT 心肌的发育至关重要，为先天性心脏病 (CHD) 和一些人类疾病的分子机制提供了新的见解。综合症。