RNA-binding proteins typically change the fate of RNA, such as stability, translation or processing. Conversely, we recently uncovered that the small non-coding vault RNA 1-1 (vtRNA1-1) directly binds to the autophagic receptor p62/SQSTM1 and changes the protein's function. We refer to this process as 'riboregulation'. Here, we discuss this newly uncovered vault RNA function against the background of three decades of vault RNA research. We highlight the vtRNA1-1-p62 interaction as an example of riboregulation of a key cellular process.

中文翻译：

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“高保管年龄”：自噬的非编码RNA控制。

RNA结合蛋白通常会改变RNA的命运，例如稳定性，翻译或加工。相反，我们最近发现，小的非编码穹顶RNA 1-1（vtRNA1-1）直接与自噬受体p62 / SQSTM1结合并改变了蛋白质的功能。我们将此过程称为“重组”。在这里，我们以三十年的穹顶RNA研究为背景，讨论这种新发现的穹顶RNA功能。我们突出显示vtRNA1-1-p62相互作用作为关键细胞过程核糖调节的一个例子。