1′-Acetoxychavicol acetate (ACA) is found in the rhizomes or seeds of Alpinia galanga and Alpinia conchigera, which are used as traditional spices in cooking and traditional medicines in Southeast Asia. ACA possesses numerous medicinal properties. Those include anticancer, antiobesity, antiallergy, antimicrobial, antidiabetic, gastroprotective, and anti-inflammatory activities. ACA is also observed to exhibit antidementia activity. Recent studies have demonstrated that combining ACA with other substances results in synergistic anticancer effects. The structural factors that regulate the activity of ACA include (1) the acetyl group at position 1′, (2) the acetyl group at position 4, and (3) the unsaturated double bond between positions 2′ and 3′. ACA induces the activation of AMP-activated protein kinase (AMPK), which regulates the signal transduction pathways, and has an important role in the prevention of diseases, including cancer, obesity, hyperlipidemia, diabetes, and neurodegenerative disorders. Such findings suggest that AMPK has a central role in different pharmacological functions of ACA, and ACA is useful for the prevention of life-threatening diseases. However, more studies should be performed to evaluate the clinical effects of ACA and to better understand its potential.

中文翻译：

---

1'-乙酰氧基查韦尔醋酸盐的药理作用，是高良姜和高良姜的根茎中的主要成分。

1'-乙酰氧基查韦尔乙酸盐（ACA）存在于高良姜和甜菜的根茎或种子中，在东南亚用作烹饪和传统药物中的传统香料。ACA具有许多药用特性。这些包括抗癌，抗肥胖，抗过敏，抗菌，抗糖尿病，胃保护和抗炎活性。还观察到ACA表现出抗痴呆活性。最近的研究表明，将ACA与其他物质组合会产生协同的抗癌作用。调节ACA活性的结构因素包括（1）位置1'的乙酰基，（2）位置4的乙酰基，和（3）位置2'和3'之间的不饱和双键。ACA可以诱导AMP激活的蛋白激酶（AMPK）的激活，从而调节信号转导途径，并且在预防包括癌症，肥胖症，高脂血症，糖尿病和神经退行性疾病。这些发现表明AMPK在ACA的不同药理功能中起着核心作用，而ACA可用于预防威胁生命的疾病。但是，应该进行更多的研究以评估ACA的临床效果并更好地了解其潜力。