Objective of this work is to investigate, for the first time, serum concentration of neuropilin-1 (NRP-1), aiming to evaluate its diagnostic performance in endometriosis and usability as a potential non-invasive serum marker of endometriosis. Two hundred women were treated laparoscopically. After laparoscopic surgery women were divided into two groups: 120 women diagnosed with endometriosis and 80 healthy women (control group). Blood samples were taken from all women undergoing laparoscopy half an hour before the induction of anesthesia, for the purpose of collection of serum. The level of NRP-1 in serum was assayed by a standardised sandwich enzyme-linked immunosorbent assay. Differences between endometriosis and healthy control group in NRP-1 levels were significant. All values were significantly and several times higher in patients group, p < .001. After receiver operating characteristic analysis, the area under curve was 0.97 (95% confidence interval: 0.941 to 0.989, p < .0001) at 11 µg/L cut-off level for NRP-1. Preliminary threshold values for NRP-1 in serum were assumed to serve as diagnostic parameters with sensitivity of 99.3% and specificity of 97.8%. Serum concentration of NRP-1 can be considered as a potentially good laboratory diagnostic, non-invasive marker for endometriosis.

这项工作的目的是第一次调查神经纤维蛋白-1（NRP-1）的血清浓度，以评估其在子宫内膜异位症中的诊断性能以及作为潜在的子宫内膜异位症无创性血清标志物的可用性。腹腔镜治疗了200名妇女。腹腔镜手术后，妇女分为两组：120名被诊断为子宫内膜异位的妇女和80名健康妇女（对照组）。在麻醉诱导前半小时从所有接受腹腔镜检查的妇女中采集血液样本，以收集血清。通过标准化的夹心酶联免疫吸附测定法测定血清中的NRP-1水平。子宫内膜异位症与健康对照组的NRP-1水平差异显着。患者组的所有值均显着且高出几倍，p  ＜.001。对接收器工作特性进行分析后，在 NRP-1的截止浓度为11 µg / L时，曲线下面积为0.97（95％置信区间：0.941至0.989，p <.0001）。血清中NRP-1的初步阈值被认为是诊断参数，敏感性为99.3％，特异性为97.8％。血清NRP-1浓度可被视为子宫内膜异位症的潜在良好实验室诊断，非侵入性标记。