Stemonae Radix, a medicinal and edible herb, has been reported to possess various pharmacological effects. In the present study, Stemonae Radix was fermented by fungi to improve the antioxidant and anti-tyrosinase activities. The results showed that Stemonae Radix fermented by Mucor circinelloides T2-12 exhibited two-folds more antioxidant and anti-tyrosinase activities than non-fermented material. The increased activity might be ascribed to the improvement of total phenolic content, hydrolyzation of glucosides and esters of phenolics and metabolism of saccharides according to ultraviolet and nuclear paramagnetic resonance spectroscopy. This paper suggested that fermenting Stemonae Radix with M. circinelloides T2-12 is effective to increase antioxidant and anti-tyrosinase effects and Stemonae Radix fermented by M. circinelloides T2-12 might be newly alternative of natural antioxidant and tyrosinase inhibitor. The present study is the first to report that pure strain fermentation processing is effective in improving the antioxidant and anti-tyrosinase activities of Stemonae Radix.

Stemonae Radix是一种药用和食用药草，据报道具有多种药理作用。在本研究中，用真菌发酵Stemonae Radix以提高抗氧化和抗酪氨酸酶的活性。结果表明，由Mucor circinelloides T2-12发酵的Staneae Radix表现出的抗氧化和抗酪氨酸酶活性是非发酵材料的两倍。活性的增加可能归因于总酚含量的提高，根据紫外和核顺磁共振波谱分析的糖苷和酚醛酸酯的水解以及糖类的代谢。本文建议用圆环分枝杆菌发酵Stemonae Radix 。T2-12有效地增加抗氧化和抗酪氨酸酶的效果和百部麦冬发酵由M.卷枝T2-12可能是新的替代天然抗氧化剂和酪氨酸酶抑制剂。本研究是第一个报告纯菌株发酵工艺可有效提高Stemonae Radix的抗氧化和抗酪氨酸酶活性的报道。