Oxidative stress has been long considered an important cause of male infertility, and sperm-derived reactive oxygen species (ROS) have been considered one of the major sources. In article number 1900205, Issue 2, Netherton et al. have improved upon current technologies for detection of true ROS-derived oxidative events from those originated by mitochondrial compounds. Moreover, the authors have isolated proteins that bear lipid aldehyde adducts, in order to verify their origin. In their paper, Netherton et al. demonstrate that sperm-derived ROS do not contribute to sperm oxidative stress, which is an important finding, given that most studies consider altered sperm a major source of seminal ROS. Moreover, adducted proteins are mostly of prostatic origin, which leads to questions regarding how and where the oxidative events occur. Under the light of this study and the methodological improvements it has brought, it may be important to revisit some foundation studies in semen and sperm oxidative stress.

中文翻译：

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精子氧化的机制：分解氧化活动的起源。

长期以来，氧化应激一直被认为是男性不育的重要原因，而精子来源的活性氧（ROS）被认为是主要来源之一。Netherton等人在文章1900205第2期中。已从检测线粒体化合物产生的真正ROS衍生的氧化事件的现有技术方面进行了改进。此外，作者还分离了带有脂质醛加合物的蛋白质，以验证其来源。Netherton等人在他们的论文中。证明精子来源的ROS不会促进精子氧化应激，这是一个重要发现，因为大多数研究都认为精子改变是精子ROS的主要来源。此外，加成蛋白主要是前列腺来源的，这引起了关于氧化事件如何以及在何处发生的问题。