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Chronic administration of plasma from exercised rats to sedentary rats does not induce redox and metabolic adaptations.
The Journal of Physiological Sciences ( IF 2.6 ) Pub Date : 2020-02-03 , DOI: 10.1186/s12576-020-00737-2
Georgios Goutianos 1 , Nikos V Margaritelis 1, 2 , Theodora Sparopoulou 1, 3 , Aristidis S Veskoukis 1, 4 , Ioannis S Vrabas 1 , Vassilis Paschalis 5 , Michalis G Nikolaidis 1 , Antonios Kyparos 1
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The present study aimed to investigate whether endurance exercise-induced changes in blood plasma composition may lead to adaptations in erythrocytes, skeletal muscle and liver. Forty sedentary rats were randomly distributed into two groups: a group that was injected with pooled plasma from rats that swam until exhaustion and a group that was injected with the pooled plasma from resting rats (intravenous administration at a dose of 2 mL/kg body weight for 21 days). Total antioxidant capacity, malondialdehyde and protein carbonyls were higher in the plasma collected from the exercised rats compared to the plasma from the resting rats. Νo significant difference was found in blood and tissue redox biomarkers and in tissue metabolic markers between rats that received the "exercised" or the "non-exercised" plasma (P > 0.05). Our results demonstrate that plasma injections from exercised rats to sedentary rats do not induce redox or metabolic adaptations in erythrocytes, skeletal muscle and liver.

中文翻译:

从运动的大鼠向久坐的大鼠长期施用血浆不会诱导氧化还原和代谢适应。

本研究旨在调查耐力运动诱发的血浆成分变化是否可能导致红细胞,骨骼肌和肝脏的适应。将四十只久坐的大鼠随机分为两组:一组从游至疲惫的大鼠中注入合并血浆,另一组从静止大鼠中注入合并血浆(静脉注射剂量为2 mL / kg体重)持续21天)。从运动大鼠收集的血浆中的总抗氧化能力,丙二醛和蛋白质羰基含量高于静止大鼠的血浆。在接受“运动”或“非运动”血浆的大鼠之间,血液和组织氧化还原生物标志物以及组织代谢标志物均未发现显着差异(P> 0.05)。
更新日期:2020-02-03
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