We previously found that equol, a metabolite of intestinal bacterial conversion from soy isoflavone daidzein, has female-specific anorectic effects. In the present study, we used seven-week-old female ovariectomized (OVX) Sprague Dawley rats to test the hypothesis that the anorectic effect of dietary daidzein may be attributed to delayed gastric emptying. Results suggest that dietary daidzein delays gastric emptying and that it has an anorectic effect with residual gastric contents, but not without gastric contents. Dietary equol significantly decreased daily food intake in the OVX rats without sleeve gastrectomy, but not in those with sleeve gastrectomy, suggesting that the accumulation of food in the stomach is required for the anorectic effect of equol to occur. These results support the hypothesis that the anorectic effect of dietary daidzein is attributed to delayed gastric emptying.

中文翻译：

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膳食黄豆苷元减少了去卵巢大鼠的食物摄入量，并导致胃排空延迟。

我们先前发现雌马酚是大豆异黄酮黄豆苷元肠细菌转化的代谢产物，具有雌性特定的厌食作用。在本研究中，我们使用七周大的雌性卵巢切除（OVX）Sprague Dawley大鼠来检验饮食中大豆苷元的厌食作用可能归因于胃排空延迟的假说。结果表明，膳食黄豆苷元可以延迟胃排空，并且具有残留胃内容物但没有胃内容物的厌食作用。饮食雌马酚可显着减少无袖胃切除术的OVX大鼠的每日食物摄入量，但无袖胃切除术的大鼠则无此发现，这表明雌马酚的厌食作用需要食物在胃中积累。