K+ channels regulate a multitude of biological processes and play important roles in a variety of diseases by controlling potassium flow across cell membranes. They are widely expressed in the central and peripheral nervous system. As a malignant tumor derived from nerve epithelium, glioma has the characteristics of high incidence, high recurrence rate, high mortality rate, and low cure rate. Since glioma cells show invasive growth, current surgical methods cannot completely remove tumors. Adjuvant chemotherapy is still needed after surgery. Because the blood-brain barrier and other factors lead to a lower effective concentration of chemotherapeutic drugs in the tumor, the recurrence rate of residual lesions is extremely high. Therefore, new therapeutic methods are needed. Numerous studies have shown that different K+ channel subtypes are differentially expressed in glioma cells and are involved in the regulation of the cell cycle of glioma cells to arrest them at different stages of the cell cycle. Increasing evidence suggests that K+ channels express in glioma cells and regulate glioma cell behaviors such as cell cycle, proliferation and apoptosis. This review article aims to summarize the current knowledge on the function of K+ channels in glioma, suggests K+ channels participating in the development of glioma.

中文翻译：

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钾离子通道及其在神经胶质瘤中的作用：一个小型综述。

K +通道通过控制钾离子跨细胞膜的流动来调节多种生物过程，并在多种疾病中起重要作用。它们在中枢和外周神经系统中广泛表达。胶质瘤是一种源于神经上皮的恶性肿瘤，具有发病率高，复发率高，死亡率高，治愈率低的特点。由于神经胶质瘤细胞显示出侵袭性生长，因此当前的外科手术方法不能完全去除肿瘤。手术后仍需要辅助化疗。由于血脑屏障和其他因素导致肿瘤中化疗药物的有效浓度降低，因此残留病变的复发率极高。因此，需要新的治疗方法。大量研究表明，不同的K +通道亚型在神经胶质瘤细胞中差异表达，并参与神经胶质瘤细胞的细胞周期调控，从而将其阻滞在细胞周期的不同阶段。越来越多的证据表明，K +通道在神经胶质瘤细胞中表达并调节神经胶质瘤细胞的行为，例如细胞周期，增殖和凋亡。这篇综述文章旨在总结有关胶质瘤中K +通道功能的当前知识，建议参与胶质瘤发展的K +通道。