Introduction: Curcumin is an important bioactive compound present in Curcuma longa, and is well known for its bioactivities such as anti-inflammatory, anticancer, antimicrobial, antiparasitic and antioxidant activity. The use of curcumin is limited owing to its poor solubility in water, fast degradation, and low bioavailability. This problem can be solved by using nano-curcumin, which is soluble in water and enhances its activity against various microbial pathogens and parasites.Areas covered: We have reviewed curcumin, curcumin-loaded nanoparticles and their activities against various pathogenic microbes (antifungal, antiviral and antiprotozoal) and parasites, as curcumin has already demonstrated broad-spectrum antimicrobial activity. It has also inhibited biofilm formation by various bacteria including Pseudomonas aeruginosa. The antimicrobial activity of curcumin can be increased in the presence of light radiation due to its photo-excitation. Further, it has been found that the activity of curcumin nanoparticles is enhanced when used in combination with antibiotics. Finally, we discussed the toxicity and safety issues of curcumin.Expert opinion: Since many microbial pathogens have developed resistance to antibiotics, the combination of curcumin with different nanoparticles will prove to be a boon for their treatment. Moreover, curcumin and curcumin-loaded nanoparticles can also be used against various parasites.

中文翻译：

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姜黄素和姜黄素负载的纳米颗粒：抗病原和抗寄生虫活性。

简介：姜黄素是一种存在于姜黄中的重要生物活性化合物，并以其抗炎，抗癌，抗菌，抗寄生虫和抗氧化等生物活性而闻名。由于姜黄素在水中的溶解性差，降解快和生物利用度低，因此其使用受到限制。纳米姜黄素可以解决此问题，纳米姜黄素可溶于水并增强其对各种微生物病原体和寄生虫的活性。研究范围：我们综述了姜黄素，载有姜黄素的纳米颗粒及其对各种病原微生物（抗真菌药，抗病毒药）的活性。和抗原生动物）和寄生虫，因为姜黄素已显示出广谱抗菌活性。它也抑制了包括铜绿假单胞菌在内的各种细菌的生物膜形成。由于存在光激发，姜黄素的抗微生物活性可以在存在光辐射的情况下提高。此外，已经发现当与抗生素组合使用时，姜黄素纳米颗粒的活性增强。最后，我们讨论了姜黄素的毒性和安全性问题。专家意见：由于许多微生物病原体已经对抗生素产生了抗药性，姜黄素与不同纳米颗粒的结合将被证明是对其治疗的福音。此外，姜黄素和负载姜黄素的纳米颗粒也可用于对抗各种寄生虫。我们讨论了姜黄素的毒性和安全性问题。专家意见：由于许多微生物病原体已经对抗生素产生了抗药性，姜黄素与不同纳米颗粒的组合将被证明是对其治疗的福音。此外，姜黄素和负载姜黄素的纳米颗粒也可用于对抗各种寄生虫。我们讨论了姜黄素的毒性和安全性问题。专家意见：由于许多微生物病原体已经对抗生素产生了抗药性，姜黄素与不同纳米颗粒的组合将被证明是对其治疗的福音。而且，姜黄素和负载姜黄素的纳米颗粒也可以用于对抗各种寄生虫。