Radiation sterilization is an effective method of bone sterilization prior to bone graft transplantation. Gamma irradiation affects the biological and mechanical properties of bone; depending on the dose of radiation. The effect of gamma irradiation on bone mechanical properties is an unwanted phenomenon. However the mechanism of the effect of irradiation on bone mechanical properties is not properly understood. In this research paper the mechanism of the effect of gamma irradiation on bovine bone is investigated using scanning electron microscopy, energy-dispersive X-rays spectroscopy and Fourier transform infrared spectroscopy techniques. Gamma irradiation affects the mineral and fiber composition of bovine bone. The mineral content of bone especially calcium, magnesium and phosphorus decrease with increasing dose of gamma radiation. At Nano-level gamma irradiation alter amide I, amide II and amide III collagen contents. High dose gamma irradiation induces collagen cross-linking reaction in bone and degrades bone properties.

中文翻译：

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伽马辐照对牛骨作用机制的研究。

辐射灭菌是骨移植移植前骨灭菌的有效方法。伽马射线照射影响骨骼的生物和机械性能；取决于辐射剂量。伽马射线照射对骨机械性能的影响是一种不需要的现象。然而，辐射对骨机械性能影响的机制尚不清楚。在本研究论文中，利用扫描电子显微镜、能量色散 X 射线光谱和傅里叶变换红外光谱技术研究了伽马射线照射对牛骨的影响机制。伽马射线照射会影响牛骨的矿物质和纤维成分。骨骼中的矿物质含量，尤其是钙、镁和磷，随着伽马辐射剂量的增加而减少。纳米级伽马射线照射改变酰胺 I、酰胺 II 和酰胺 III 胶原蛋白含量。高剂量伽马射线照射会诱导骨中胶原蛋白交联反应并降低骨特性。