The present study aimed to evaluate the mechanical and degradative properties of poly(L-co-D,L-lactic acid)/silicate bioactive glass fibers (PLDLA/SGFs) composite pins in vivo. Both PLDLA and PLDLA/SGFs pins were inserted into the erector spinae muscles and femurs of beagle dogs and were harvested 6, 12, 16, 26, 52, 78, and 104 weeks after insertion. Bone formation around the pins was evaluated by micro-computed tomography. Mechanical properties were measured by the shear strength test. Thermogravimetric analysis, differential scanning calorimetry, and gel permeation chromatography were used to assess the degradation of these materials. The surface and cross-sectional morphology of both pins were observed using a scanning electron microscope. The experimental data demonstrated that PLDLA/SGFs pins can support new bone formation due to the influence of bioactive glass fibers. PLDLA/SGFs composite pins had higher initial shear strength and were relatively stable for at least 26 weeks. The addition of bioactive glass fibers accelerated the degradation rate of the composite pins. Thus, PLDLA/SGFs composite pins have promising potential for bone fixation applications.

中文翻译：

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比格尔模型中具有生物活性玻璃纤维的PLDLA可生物降解销的机械和降解性能。

本研究旨在评估体内的聚（L-co-D，L-乳酸）/硅酸盐生物活性玻璃纤维（PLDLA / SGFs）复合材料钉的机械和降解性能。将PLDLA和PLDLA / SGFs销钉都插入比格犬的竖脊肌和股骨中，并在插入后第6、12、16、26、52、78和104周收获。通过微计算机断层扫描评估销周围的骨形成。通过剪切强度测试测量机械性能。使用热重分析，差示扫描量热法和凝胶渗透色谱法评估这些材料的降解。使用扫描电子显微镜观察两个销的表面和横截面形态。实验数据表明，由于生物活性玻璃纤维的影响，PLDLA / SGFs销钉可以支持新的骨形成。PLDLA / SGFs复合材料销钉具有较高的初始剪切强度，并且在至少26周内相对稳定。添加生物活性玻璃纤维可加快复合材料销钉的降解速度。因此，PLDLA / SGFs复合销钉在骨固定应用中具有广阔的发展潜力。