Systemic sclerosis (SSc) is a complex, heterogeneous autoimmune connective tissue disease. Autologous hematopoietic stem‐cell transplantation (AHSCT) has emerged as a valuable treatment option for rapidly progressive diffuse cutaneous SSc (dcSSc) patients, and thus far is the only treatment that has been shown to have a long‐term clinical benefit. AHSCT is thought to reintroduce immune homeostasis through elimination of pathogenic self‐reactive immune cells and reconstitution of a new, tolerant immune system. However, the mechanism of action underlying this reset to tolerance remains largely unknown. In this study we review the immune mechanisms underlying AHSCT for SSc, with a focus on the role of the innate immune cells, including monocytes and natural killer (NK) cells, in restoring immune balance after AHSCT.

中文翻译：

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在自体造血干细胞移植的背景下，先天免疫细胞在系统性硬化中的作用。

系统性硬化症（SSc）是一种复杂的异质性自身免疫性结缔组织病。自体造血干细胞移植（AHSCT）已成为快速进行性弥漫性皮肤SSc（dcSSc）患者的一种有价值的治疗选择，迄今为止，这是唯一显示出长期临床益处的治疗方法。AHSCT被认为可通过消除病原性自反应性免疫细胞并重建新的耐受性免疫系统来重新引入免疫稳态。但是，这种恢复耐受性的作用机理仍然未知。在这项研究中，我们综述了AHSCT对SSc的免疫机制，重点是先天性免疫细胞（包括单核细胞和自然杀伤（NK）细胞）在恢复AHSCT后的免疫平衡中的作用。