The germline encoded innate immunity governs eukaryotic host defense through both hematopoietic and non-hematopoietic cells, whereas adaptive immunity actions mainly via T cells and B cells characterized by their somatic genetic diversification of antigen-specific responses. Human inborn errors of innate immunity typically underlie infectious diseases. Disturbed innate immunity can additionally result in auto-inflammation. Here, we review inborn errors of innate immunity that have been recently discovered as well as new insights into previously described inborn errors of innate immunity.

中文翻译：

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最近人类先天免疫的遗传错误导致对感染的易感性增加。

种系编码的先天免疫通过造血和非造血细胞控制真核宿主防御，而适应性免疫作用主要通过 T 细胞和 B 细胞，其特征是抗原特异性反应的体细胞遗传多样化。先天免疫的人类先天性错误通常是传染病的基础。受干扰的先天免疫还会导致自身炎症。在这里，我们回顾了最近发现的先天免疫先天性错误以及对先前描述的先天免疫先天性错误的新见解。