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A Ninhydrin-Type Urea Sorbent for the Development of a Wearable Artificial Kidney.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-02-17 , DOI: 10.1002/mabi.201900396
Jacobus A W Jong 1, 2 , Yong Guo 1 , Diënty Hazenbrink 2 , Stefania Douka 1 , Dennis Verdijk 3 , Johan van der Zwan 4 , Klaartje Houben 4 , Marc Baldus 4 , Karina C Scheiner 1 , Remco Dalebout 5 , Marianne C Verhaar 2 , Robert Smakman 6 , Wim E Hennink 1 , Karin G F Gerritsen 2 , Cornelus F van Nostrum 1
Affiliation  

The aim of this study is to develop polymeric chemisorbents with a high density of ninhydrin groups, able to covalently bind urea under physiological conditions and thus potentially suitable for use in a wearable artificial kidney. Macroporous beads are prepared by suspension polymerization of 5‐vinyl‐1‐indanone (vinylindanone) using a 90:10 (v/v) mixture of toluene and nitrobenzene as a porogen. The indanone groups are subsequently oxidized in a one‐step procedure into ninhydrin groups. Their urea absorption kinetics are evaluated under both static and dynamic conditions at 37 °C in simulated dialysate (urea in phosphate buffered saline). Under static conditions and at a 1:1 molar ratio of ninhydrin: urea the sorbent beads remove ≈0.6–0.7 mmol g−1 and under dynamic conditions and at a 2:1 molar excess of ninhydrin ≈0.6 mmol urea g−1 sorbent in 8 h at 37 °C, which is a step toward a wearable artificial kidney.

中文翻译:

用于可穿戴人工肾脏发育的茚三酮型尿素吸收剂。

这项研究的目的是开发具有高密度茚三酮基团的聚合物化学吸附剂,能够在生理条件下与尿素共价结合,因此潜在地适用于可穿戴的人造肾脏。大孔珠是通过使用甲苯和硝基苯的90:10(v / v)混合物作为致孔剂,通过5-乙烯基-1-茚满酮(乙烯基茚满酮)的悬浮聚合制备的。随后将茚满酮基团一步一步氧化成茚三酮基团。在模拟透析液(磷酸盐缓冲液中的尿素)中,在静态和动态条件下,在37°C下评估其尿素吸收动力学。在静态条件下,茚三酮与尿素的摩尔比为1:1时,吸附剂珠粒去除≈0.6–0.7 mmol g -1在动态条件下,在37°C下8小时内,茚三酮≈0.6mmol尿素g -1吸附剂摩尔比为2:1时,这是朝着可穿戴人造肾脏迈出的一步。
更新日期:2020-02-17
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