Homozygous and compound heterozygous Miniature horses for ACAN alleles D1, D2, D3* and D4 exhibit chondrodysplastic dwarfism (OMIA 001271-9796). In a previous study, the carrier rate for these four alleles, combined, was 26.2%. The purpose of this study was to investigate whether carriers of these dwarfism-causing alleles had a shorter withers height than non-carriers. A total of 245 Miniature horses were tested for these four ACAN alleles and also were measured for withers height. Of these horses, 98 were carriers and 147 were non-carriers. A statistically significant difference of 1.43 inches was observed with the carriers being shorter (P = 1.72E - 11). The range of heights for the two groups overlapped, indicating that other factors, including genes, have an impact on withers height. However, the high carrier rate of these dwarfism-causing variants may be due to selection for decreased height.

中文翻译：

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用于马中ACAN矮化等位基因的杂合子的身高降低。

纯合子和复合杂合子用于ACAN等位基因D1，D2，D3 *和D4的微型马表现出软骨发育不良矮化症（OMIA 001271-9796）。在先前的研究中，这四个等位基因的携带率合计为26.2％。这项研究的目的是调查这些导致侏儒症的等位基因携带者的枯萎高度是否比非携带者矮。总共测试了245匹微型马的这四个ACAN等位基因，并且还测量了其凋谢高度。在这些马中，有98具是携带者，有147具是非携带者。观察到统计学上的显着差异为1.43英寸，而载体较短（P = 1.72E-11）。两组的身高范围重叠，表明其他因素，包括基因，对凋谢高度都有影响。然而，