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Novel insights into cerebral palsy.
Journal of Muscle Research and Cell Motility ( IF 1.8 ) Pub Date : 2020-02-17 , DOI: 10.1007/s10974-020-09577-4
Else Marie Bartels 1 , Lise Korbo 1 , Adrian P Harrison 2
Affiliation  

Cerebral palsy (CP) is a neurodevelopmental disorder characterized by abnormalities of muscle tone, movement and motor skills, and is attributed to injury to the developing brain. CP affects about 1 in 500 neonates. CP shows clinical features which evolve with age, and these may over time lead to deterioration of motor function although the lesion to the developing brain is non-progressive. The underlying causes for CP remain unclear. Based on recent research we are able to give a physiological explanation on the appearance and development of the condition. The damage to the central nervous system causes a change in collagen structure, with a higher level of deposition of collagen around the muscles, increasing throughout life. Assuming this premise is correct, the question is, will it by any treatment be possible to delay or prevent this collagen accumulation in the CP muscles, thereby giving CP patients a better prognosis in the future.

中文翻译:

对脑瘫的新见解。

脑性麻痹 (CP) 是一种神经发育障碍,其特征是肌肉张力、运动和运动技能异常,并且归因于发育中的大脑的损伤。CP 影响大约五分之一的新生儿。CP 显示出随着年龄增长而演变的临床特征,这些可能随着时间的推移导致运动功能的恶化,尽管发育中的大脑的损伤是非进行性的。CP 的根本原因尚不清楚。根据最近的研究,我们能够对这种情况的出现和发展给出生理学解释。对中枢神经系统的损害导致胶原蛋白结构发生变化,肌肉周围胶原蛋白沉积水平更高,终生增加。假设这个前提是正确的,问题是,
更新日期:2020-04-14
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