Metatranscriptomics reveals that the death of a Mongolian wild ass was caused by Clostridium botulinum in Inner Mongolia, China.,The Journal of Veterinary Diagnostic Investigation

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Metatranscriptomics reveals that the death of a Mongolian wild ass was caused by Clostridium botulinum in Inner Mongolia, China.
The Journal of Veterinary Diagnostic Investigation ( IF 1.2 ) Pub Date : 2020-02-15 , DOI: 10.1177/1040638720905314
Jian-Wei Shao _{1,

2,

3} , Xiang-Dong Ruan _{1,

2,

3} , Xin-Cheng Qin _{1,

2,

3} , Jie Yan _{1,

2,

3} , Yong-Zhen Zhang _{1,

2,

3}

Affiliation

Clostridium botulinum is an important pathogen that causes botulism in humans and animals worldwide. C. botulinum group III strains, which produce a single toxin of type C or D or a chimeric toxin of type C/D or D/C, are responsible for botulism in a wide range of animal species including cattle and birds. We used unbiased high-throughput RNA sequencing (i.e., metatranscriptomics) to identify a strain of group III C. botulinum from a deceased Mongolian wild ass (Equus hemionus). The strain was closely related to some European strains. Genetic analysis of the recovered bacterial sequences showed that the C. botulinum strain identified might represent a type C/D strain of group III. Infection by C. botulinum producing the mosaic toxin of type C/D is the most likely cause of the death of the wild ass.

更新日期：2020-02-15

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