Primary Objective: Limited available therapeutics for ischemic stroke necessitate dire need of designing novel strategies for combating ischemic pathophysiological cascade among which neuroprotective strategies emerge as positive approaches. The neuropeptide prolactin is a pleiotropic hormone that affects various physiological conditions and reportedly combats neurotoxicity, neuronal stress and provides neuroprotection to hippocampal neurons in vitro.Research Design: The study explores the ability of prolactin in conferring neuroprotection in global cerebral ischemia in vivo and attempts to optimize the dose of prolactin which will be effective for the same.Methods and Procedure: Global cerebral ischemia was induced in male rats by bilateral common carotid occlusion (BCCAO) and different physiological and biochemical parameters were evaluated. Also, cerebral infarction and percentage of brain edema were measured.Results: The results revealed that prolactin significantly reduces cerebral infarct, brain water content and restores the physiological conditions like blood pressure, heart rate and cerebral blood flow. Also, prolactin markedly reduces the increased levels of the neurotransmitters (ɣ-aminobutyric acid and glutamate), cerebral calcium and nitrate in different brain compartments of ischemic rats.Conclusion: Prolactin is able to ameliorate ischemia-reperfusion injury in rat brain and might be a potent candidate for further neuro-therapeutics development.

中文翻译：

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催乳素通过赋予神经保护作用来减轻大鼠模型的整体脑缺血损伤。

主要目标：缺血性中风的有限可用疗法迫切需要设计新的策略来对抗缺血性病理生理学级联反应，其中神经保护策略应运而生。神经肽催乳素是一种多效激素，可影响各种生理状况，并据称可在体外对抗神经毒性，神经元应激并为海马神经元提供神经保护。方法和步骤：通过双侧颈总动脉闭塞（BCCAO）诱导雄性大鼠全脑缺血，并评估不同的生理和生化参数。结果：结果表明，催乳素能显着减少脑梗塞，脑含水量并恢复血压，心率和脑血流量等生理状况。此外，催乳素可明显降低缺血大鼠不同脑区神经递质（α-氨基丁酸和谷氨酸），脑钙和硝酸盐水平的升高。结论：催乳素能够减轻大鼠脑的缺血再灌注损伤，可能是一种缺血性脑损伤。神经疗法进一步发展的强大候选者。大脑中的水分，并能恢复血压，心率和脑血流量等生理状况。此外，催乳素能明显减少缺血大鼠不同脑区神经递质（α-氨基丁酸和谷氨酸），脑钙和硝酸盐水平的升高。神经疗法进一步发展的强大候选者。大脑中的水分，并能恢复血压，心率和脑血流量等生理状况。此外，催乳素可明显降低缺血大鼠不同脑区神经递质（α-氨基丁酸和谷氨酸），脑钙和硝酸盐水平的升高。结论：催乳素能够减轻大鼠脑的缺血再灌注损伤，可能是一种缺血性脑损伤。神经疗法进一步发展的强大候选者。