We investigated the pathogenesis of skin lesions due to hypothyroidism and hyperthyroidism in rats. We used 30 rats allocated into hypothyroidism, hyperthyroidism and control groups. Blood samples were evaluated for levels of thyroid stimulating hormone (TSH), tri-iodothyronine (T3) and thyroxine (T4). Skin samples were examined for melan-A, lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1), cluster of differentiation 31 (CD31), protein gene product 9.5 (PGP9.5), calretinin, chromogranin, synaptophysin and pancytokeratin. Histopathological examination of the skin sections revealed thickened epidermis in the hyperthyroidism group due to an increased number of cells, and a decreased number of hair follicles and epithelial cell rows in the epidermis with an increased number of fat cells in the dermis of the rats in the hypothyroidism group. No significant difference was observed in the immunoreactions of pancytokeratin, PGP9.5, CD31 and synaptophysin among the groups. The hyperthyroidism and hypothyroidism groups exhibited a marked increase in melan-A immunoreaction. Expression of LYVE-1, chromogranin and calretinin was increased in the hyperthyroidism group and decreased in the hypothyroidism group. We found that melan-A, LYVE-1, chromogenin and calretinin play an important role in the pathogenesis of skin lesions caused by thyroid disorders.

我们调查了大鼠甲状腺功能减退和甲状腺功能亢进引起的皮肤病变的发病机制。我们将30只大鼠分为甲状腺功能减退，甲状腺功能亢进和对照组。评估血液样本中的甲状腺刺激激素（TSH），三碘甲状腺素（T3）和甲状腺素（T4）的水平。检查皮肤样品中的黑色素A，淋巴管内皮透明质酸受体1（LYVE1），分化簇31（CD31），蛋白基因产物9.5（PGP9.5），钙网蛋白，嗜铬粒蛋白，突触素和全细胞角蛋白。皮肤切片的组织病理学检查显示，甲亢组的表皮增厚是由于细胞数量增加，甲状腺功能减退组大鼠的表皮毛囊和上皮细胞排数量减少，而真皮中的脂肪细胞数量增加。各组之间的全细胞角蛋白，PGP9.5，CD31和突触素的免疫反应没有显着差异。甲状腺功能亢进症和甲状腺功能减退症组的黑色素A免疫反应显着增加。甲状腺功能亢进组LYVE-1，嗜铬粒蛋白和钙网蛋白的表达升高，而甲状腺功能减退组的表达降低。我们发现，黑色素A，LYVE-1，色原蛋白和钙调蛋白在甲状腺疾病引起的皮肤病变的发病机理中起重要作用。甲状腺功能亢进和甲状腺功能减退组的黑色素A免疫反应显着增加。甲状腺功能亢进组LYVE-1，嗜铬粒蛋白和钙网蛋白的表达升高，而甲状腺功能减退组的表达降低。我们发现，黑色素A，LYVE-1，色原蛋白和钙调蛋白在甲状腺疾病引起的皮肤病变的发病机理中起重要作用。甲状腺功能亢进和甲状腺功能减退组的黑色素A免疫反应显着增加。甲状腺功能亢进组LYVE-1，嗜铬粒蛋白和钙网蛋白的表达升高，而甲状腺功能减退组的表达降低。我们发现，黑色素A，LYVE-1，色原蛋白和钙调蛋白在甲状腺疾病引起的皮肤病变的发病机理中起重要作用。