Colorectal cancer is considered to be one of the major causes of morbidity and mortality all over the world. T Follicular helper (TFH) and T follicular regulatory (TFR) cells are specialized providers of T-cells to help B-cells and shaping germinal centers (GC) response. Recent researches reported a high percentage of TFH and TFR in different infectious diseases and certain malignancies. However, their functional role in human colorectal cancer (CRC) is relatively unknown. Furthermore, recent studies show that the interaction of both TFH cells and TFR cells are essential to promote several diseases. Under the control of specific cytokines and B-cell lymphoma 6 transcription factor (Bcl-6), the major transcription factor of TFH cells, TFH, can expand to the other distinct CD4 + T helper cells (TH1, TH2, and TH17) which exert a different role in the development of CRC. This review aims to discuss these suggested roles of the two-opposite subset of follicular T cells in colorectal cancer immune pathogenesis.

中文翻译：

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大肠癌中的T滤泡辅助细胞和T滤泡调节细胞：复杂的相互作用。

大肠癌被认为是全世界发病率和死亡率的主要原因之一。T滤泡辅助细胞（TFH）和T滤泡调节（TFR）细胞是T细胞的专门提供者，可帮助B细胞和塑造生发中心（GC）的反应。最近的研究报道，在不同的传染病和某些恶性肿瘤中，TFH和TFR的比例很高。然而，它们在人类大肠癌（CRC）中的功能作用还相对未知。此外，最近的研究表明，TFH细胞和TFR细胞的相互作用对于促进多种疾病至关重要。在特定细胞因子和B细胞淋巴瘤6转录因子（Bcl-6）的控制下，TFH细胞的主要转录因子TFH可以扩展到其他不同的CD4 + T辅助细胞（TH1，TH2，和TH17）在CRC的发生中发挥不同的作用。这篇综述旨在讨论卵泡T细胞的两个相反亚群在结肠直肠癌免疫发病机理中的这些建议作用。