Retinyl palmitate was encapsulated in wax matrix by melt dispersion for the purpose of economic and sustainable cosmeceutical formulation with minimum use of synthetic chemicals. We evaluated the effect of different process variables of microencapsulation by melt dispersion. In this study, a three level definitive screening design was applied, where the microcapsule properties were analysed through statistical analysis to understand the effect of four process variables: type of wax, theoretical loading capacity, surface concentration and stirring speed. Microparticles were characterised for size using image analysis; loading capacity and encapsulation efficiency using ultraviolet-visible spectroscopy; antioxidant activity through DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Melt dispersion method was effective to produce microcapsules with a spherical shape and mean size as small as 28 µm. The encapsulation efficiency ranged 60-80%. Theoretical loading capacity (p-value = 0.00232, significance level, α = 1%) and surfactant% (p = 0.0573, α = 10%) were found to be the most significant factors to control the actual loading capacity and size of microcapsules.

中文翻译：

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棕榈酸视黄酯通过熔融分散体微囊化，用于化妆品。

棕榈酸视黄酯通过熔融分散包封在蜡基质中，目的是经济和可持续的药妆配方，同时尽量减少合成化学品的使用。我们通过熔融分散评估了微囊化的不同工艺变量的影响。在这项研究中，采用了三级确定性筛选设计，其中通过统计分析对微胶囊的性能进行了分析，以了解四个工艺变量的影响：蜡的类型，理论负载量，表面浓度和搅拌速度。使用图像分析表征微粒的尺寸；紫外可见光谱法的负载能力和封装效率；通过DPPH（2,2-二苯基-1-picylhydrazyl）测定抗氧化活性。熔体分散法可有效生产球形且平均粒径小至28 µm的微胶囊。封装效率为60-80％。理论上的负载能力（p值= 0.00232，显着性水平，α= 1％）和表面活性剂％（p = 0.0573，α= 10％）是控制微胶囊实际负载能力和尺寸的最重要因素。