PCOS (Polycystic Ovary Syndrome) occurs due to hyperandrogenism, excessive androgen, abnormal growth, steroidogenesis and seems to be associated with abnormal Vascular endothelial growth factor (VEGF) level in serum. The treatment is provided on the basis of body symptoms to mute the excess production of hormone. The study assessed the effect of prednisolone treatment on the concentration of VEGF, pregnancy outcomes and variants of VEGF SNPs. In the current retrospective study, the samples were collected from PCOS female patients who received prednisolone and those who did not received it, were compared along with control, in terms of pregnancy results and the association complications. The results inferred that the prednisolone made the concentration of VEGF significantly to normal levels along with other pregnancy-related and growth-related hormones. But the reduced normal limits were achieved only among few patients whereas no significant improvement found in the women who received prednisolone and control, in terms of pregnancy outcomes or complications. Further, there were no relations between the impact of treatment and the variants of VEGF SNPs. To conclude, there is no solid evidence found in the current study with regards to notable beneficial effect when the patients were treated with prednisolone, either in pregnancy outcomes or VEGF SNPs. The current study results should be considered only as a preliminary one since the genetic polymorphisms tend to exhibit different results based on population, ethnic groups etc. The results yielded may not be generalized due to differences in genetic background.

中文翻译：

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泼尼松龙对多囊卵巢综合征女性子宫内膜VGEF浓度，基因多态性和妊娠结局的影响：一项回顾性队列研究。

PCOS（多囊卵巢综合征）的发生是由于雄激素过多，雄激素过多，生长异常，类固醇生成，并且似乎与血清中血管内皮生长因子（VEGF）水平异常有关。根据身体症状提供治疗，以消除过多的激素产生。该研究评估了泼尼松龙治疗对VEGF浓度，妊娠结局和VEGF SNP变异的影响。在当前的回顾性研究中，从接受泼尼松龙治疗的PCOS女性患者和未接受泼尼松龙的女性患者中收集样品，并与对照，妊娠结果和相关并发症进行比较。结果推断，泼尼松龙与其他妊娠相关和生长相关激素一起使VEGF的浓度显着达到正常水平。但是降低的正常限值仅在少数患者中实现，而接受强的松龙和对照的妇女在妊娠结局或并发症方面未见明显改善。此外，在治疗效果和VEGF SNPs变体之间没有关系。总而言之，在当前的研究中，尚无确凿的证据表明当用泼尼松龙治疗患者时，无论在妊娠结局还是在VEGF SNPs方面，均具有显着的有益作用。由于遗传多态性倾向于根据人口，种族等呈现出不同的结果，因此当前的研究结果应仅作为初步研究。