1. The purpose of the present study was to determine if an intraperitoneal injection of two toll-like receptor-7 (TLR7) agonists, imiquimod and resiquimod, affect feed intake, voluntary activity, cloacal temperature, crop-emptying rate, plasma corticosterone (CORT) and glucose concentrations, and splenic gene expression of cytokines in chicks (Gallus gallus).

2. Although intraperitoneal injection of 100 µg imiquimod significantly increased splenic gene expression of interleukin-1β (IL-1β), IL-6, IL-8, and interferon-γ (IFN-γ), it did not affect feed intake, voluntary activity, cloacal temperature, crop-emptying rate or plasma constituents.

3. Intraperitoneal injection of 100 µg resiquimod significantly decreased feed intake, voluntary activity, cloacal temperature, crop-emptying rate and increased plasma corticosterone concentrations.

4. Intraperitoneal injection of resiquimod significantly increased splenic gene expression of IL-1β, IL-6, IL-8, IFN-γ, and tumour necrosis factor-like cytokine 1A.

5. The results showed that activation of TLR7 is associated with anorexia, hypoactivity, hypothermia, disturbance of feed passage in the digestive tract and the response to stress in chicks.

1. 本研究的目的是确定腹腔注射两种 toll 样受体 7 (TLR7) 激动剂咪喹莫特和雷西莫特是否会影响采食量、自主活动、泄殖腔温度、作物排空率、血浆皮质酮 ( CORT) 和葡萄糖浓度，以及小鸡 ( Gallus gallus ) 中细胞因子的脾基因表达。

2、腹腔注射100μg咪喹莫特虽然显着增加脾脏中白介素1β（IL-1β）、IL-6、IL-8和干扰素-γ（IFN-γ）基因表达，但不影响采食量，自愿活动、泄殖腔温度、作物排空率或血浆成分。

3. 腹腔注射 100 µg 雷西莫特显着降低了采食量、自主活动、泄殖腔温度、作物排空率并增加了血浆皮质酮浓度。

4.腹腔注射雷西莫特显着增加脾脏基因IL-1β、IL-6、IL-8、IFN-γ和肿瘤坏死因子样细胞因子1A的表达。

5.结果表明，TLR7的激活与雏鸡厌食、活动力减退、体温过低、消化道采食障碍和应激反应有关。