Background: Increased micronuclei (MNi) frequencies in human lymphocytes are an indicator of chromosome instability and could be influenced by different exogenous and endogenous factors. The increased exposure to environmental pollutants has led to the awareness of the necessity for constant monitoring of urban human populations.Aim: We evaluated the MNi frequency in a sample belonging to the non-occupationally exposed population of Turin (North-Western Italy). A possible effect of body mass index, age and sex on the genomic damage levels was also investigated.Subjects and Methods: The study included 150 subjects. MNi, nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) were scored in 1,000 lymphocytes per subject.Results: The MNi, NPBs and NBUDs average frequencies (‰ ± S.D.) were 7.19 ± 2.51, 1.65 ± 1.54 and 2.07 ± 1.76, respectively. Turin shows one of the highest MNi frequencies with respect to other Italian cities and European regions. A significant correlation was found between MNi, NPBs, NBUDs frequencies, age and body mass index.Conclusion: Baseline MNi frequency was established in a sample of a city, like Turin, exposed to high levels of environmental pollutants. We hope that the results of this study can be used as a stimulus for future biomonitoring programmes in other Italian and globally distributed cities.

中文翻译：

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生活在都灵（意大利北部）的健康受试者的外周血淋巴细胞中的微核频率：体重指数，年龄和性别的贡献。

背景：人类淋巴细胞中微核（MNi）频率的增加是染色体不稳定的指标，并可能受不同的外源性和内源性因素影响。环境污染物暴露的增加导致人们意识到有必要对城市人口进行持续监测。目的：我们评估了都灵（意大利西北部）非职业暴露人口样本中的MNi频率。还研究了体重指数，年龄和性别对基因组损伤水平的可能影响。受试者和方法：该研究包括150名受试者。MNi，核质桥（NPBs）和核芽（NBUDs）在每位受试者的1,000份淋巴细胞中评分。结果：MNi，NPB和NBUDs的平均频率（‰±SD）分别为7.19±2.51、1.65±1.54和2.07±1.76 。都灵是意大利其他城市和欧洲地区MNI频率最高的国家之一。MNI，NPBs，NBUDs频率，年龄和体重指数之间存在显着相关性。结论：基线MNi频率是在一个城市样本中建立的，例如都灵，暴露于高水平的环境污染物。我们希望这项研究的结果可以被用于其他意大利和全球分布城市的未来生物监测计划的刺激。