CONTEXT Parkinson's disease (PD) has devastating effects on quality of life (QoL), but there is no instrument that has been developed for Hindi-speaking persons with Parkinson's disease (PWP). OBJECTIVE The objective of this study was to develop and validate an instrument in Hindi language to measure health-related QoL (HRQoL) in PWP. SUBJECTS AND METHODS Literature review and interviews of stakeholders were done to create a pool of 68 items to develop a questionnaire. Self-rated global QoL item was also included in the questionnaire. Questionnaire was tested on 300 Hindi-speaking PWP. Item reduction was achieved through factor analysis and clinimetrics to finalize the QoL in PD (QLPD) instrument. Validity and reliability of the QLPD were tested. RESULTS "QLPD" is a 45-item instrument with nine subscales, namely, activities of daily living, mobility, psychological, fear, social, family, treatment, finance, and nonmotor symptom subscales. Internal consistency of QLPD's summary score and all subscales except treatment subscale was high (α = 0.74-0.94). Intraclass correlation coefficient between summary score and global QoL was 0.79. Summary score and subscale scores were significantly different (P < 0.0001) for predefined five categories on global QoL (very good to very bad). QLPD subscales exhibited good convergent and divergent validity with subscales of 39-item PD questionnaire and short form-36 scale. Higher Hoehn and Yahr stage, lower monthly per capita income, and higher levodopa equivalent daily dosage were found to be independently associated with poor HRQoL. CONCLUSION QLPD is a valid and reliable instrument to measure HRQoL in Hindi-speaking PWP.

中文翻译：

---

帕金森病仪器中生活质量的开发和验证。

背景 帕金森病 (PD) 对生活质量 (QoL) 具有破坏性影响，但目前还没有针对说印地语的帕金森病 (PWP) 患者开发的工具。目的 本研究的目的是开发和验证一种印地语工具，用于测量 PWP 中与健康相关的生活质量 (HRQoL)。主题和方法 进行了文献回顾和利益相关者访谈，以创建一个包含 68 个项目的库，以开发问卷。自评全球生活质量项目也包括在问卷中。问卷在 300 个讲印地语的 PWP 上进行了测试。通过因子分析和临床计量学来完成项目减少，以最终确定 PD 中的生活质量 (QLPD) 仪器。测试了 QLPD 的有效性和可靠性。结果“QLPD”是一个 45 项的工具，有 9 个分量表，即，日常生活活动、活动能力、心理、恐惧、社交、家庭、治疗、财务和非运动症状分量表。QLPD 总分和除治疗分量表外的所有分量表的内部一致性都很高（α = 0.74-0.94）。总分与整体生活质量之间的组内相关系数为 0.79。对于全球 QoL 的预定义五个类别（非常好到非常差），总分和子量表分数有显着差异（P < 0.0001）。QLPD 分量表与 39 项 PD 问卷和简表 36 量表的分量表表现出良好的收敛效度和发散效度。发现较高的 Hoehn 和 Yahr 分期、较低的月人均收入和较高的左旋多巴当量日剂量与较差的 HRQoL 独立相关。