BACKGROUND Deep brain stimulation (DBS) is an accepted modality of treatment in patients with Parkinson's disease (PD). Although DBS was approved in advanced PD, it is being done in early PD as well. It was mainly developed to help the patients of PD to overcome the adverse motor effects associated with treatment and treatment failure. OBJECTIVE The objective is to study the efficacy of subthalamic nucleus (STN)-DBS procedure in patients with PD. MATERIALS AND METHODS This was a prospective, single-center, follow-up observational study using a direct, structured interview of 40 selected PD patients. Preoperative assessment using Unified PD Rating Scale-III (UPDRS-III), Montreal Cognitive Assessment (MOCA), and Parkinson's Disease Questionnaire-39 were done. All the patients underwent DBS. Postoperatively, similar assessment was done during follow-up period of 6 months. The results were analyzed using Student's t-test. RESULTS The total score of UPDRS-III was reduced by 35% after STN-DBS intervention which was statistically significant (P < 0.05). STN-DBS intervention was successful in significantly reducing all UPDRS-III subscores but failed to reduce the scores in case of postural stability. MOCA scores of the patients were not found to be affected by STN-DBS intervention (P = 0.1466). Similar findings were also observed for MOCA subscores, but there was significant improvement of verbal fluency in all patients. Quality of life(QoL) improved significantly in all patients after STN-DBS intervention in all areas. Lower baseline UPDRS-III scores were found to enhance the QoL both in "off" and "on" state. However, prolonged disease duration and older age at PD onset were found to be hampering factors in the improvement of QoL. CONCLUSIONS STN-DBS is a safe procedure and can be performed in all patients of PD who develop disabling motor fluctuations to improve their QoL irrespective early or advanced disease.

中文翻译：

---

晚期帕金森病患者双侧丘脑底核深部脑刺激的功能结果：一项前瞻性研究。

背景技术深部脑刺激（DBS）是帕金森病（PD）患者公认的治疗方式。虽然 DBS 在晚期 PD 中被批准，但它也在早期 PD 中进行。它主要是为了帮助 PD 患者克服与治疗和治疗失败相关的不良运动影响而开发的。目的 研究底丘脑核（STN）-DBS 手术对 PD 患者的疗效。材料和方法 这是一项前瞻性、单中心、随访观察研究，对 40 名选定的 PD 患者进行了直接、结构化的访谈。使用统一 PD 评定量表-III (UPDRS-III)、蒙特利尔认知评估 (MOCA) 和帕金森病问卷 39 进行术前评估。所有患者均接受了 DBS。术后，在 6 个月的随访期间进行了类似的评估。使用学生 t 检验分析结果。结果STN-DBS干预后UPDRS-III总分降低35%，具有统计学意义（P<0.05）。STN-DBS 干预成功地显着降低了所有 UPDRS-III 子分数，但在姿势稳定性的情况下未能降低分数。未发现患者的 MOCA 评分受 STN-DBS 干预的影响（P = 0.1466）。MOCA 子评分也观察到类似的结果，但所有患者的语言流利度都有显着改善。STN-DBS干预后所有患者的生活质量（QoL）在所有地区都有显着改善。发现较低的基线 UPDRS-III 分数可提高“关闭”和“开启”状态下的 QoL。然而，发现疾病持续时间延长和 PD 发病年龄较大是改善 QoL 的阻碍因素。结论 STN-DBS 是一种安全的手术，可以在所有出现致残性运动波动以改善其生活质量的 PD 患者中进行，无论早期或晚期疾病。