INTRODUCTION The aim of the study was to establish a two-dimensional system based on organic and functional biological age (BA) using a biomarker of organic and functional impairment with aging for precisely assessing roles of natural aging and other risk factors in chronic disease. MATERIAL AND METHODS The index of organic mild impairment, which is similar to the frailty index, was determined with imaging parameters as organic BA. The functional BA was calculated with the following formula: Functional BA = [systolic - diastolic BP (mm Hg)] × waist circumference2 (m) × height0.5 (m)/weight (kg). A total of 1047 subjects undergoing routine health examination were randomly selected to establish a system with organic BA on the X-axis, functional BA on the Y-axis; organic and functional BAs from chronological age with 60 years as a center point of the coordinate system. A total of 85 patients with type 2 diabetes controls were recruited to verify the system. RESULTS Organic and functional BA contributed to chronological age almost equally. Both organic and functional BA increased with chronological age in the two-dimensional system for a random population. There were significant difference for distribution between diabetes and control groups in two-dimensional system (p < 0.05). That both more in quadrant II and lesser in quadrant IV for diabetes were suggested that diabetes was more sensitive to other risk factors than aging. CONCLUSIONS Combination of the two BAs could precisely recognized aging and other risk factors according to locations of the disease in each quadrant and quantitatively assessed status of nature aging and disease-related aging in a individual.

中文翻译：

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基于随年龄增长的器质性和功能性损伤的二维系统精确评估慢性病的危险因素。

引言 本研究的目的是建立一个基于器官和功能性生物学年龄 (BA) 的二维系统，使用伴随衰老的器官和功能障碍的生物标志物来精确评估自然衰老和其他危险因素在慢性疾病中的作用。材料与方法 器质性轻度损伤指数与虚弱指数相似，成像参数为器质性BA。功能性 BA 的计算公式如下：功能性 BA = [收缩压 - 舒张压 (mm Hg)] × 腰围 2 (m) × 身高 0.5 (m)/体重 (kg)。随机抽取1047名接受常规健康检查的受试者，建立以有机BA为X轴、功能BA为Y轴的系统；以 60 岁为坐标系中心点的实足年龄的有机和功能 BA。共招募了 85 名 2 型糖尿病对照患者来验证该系统。结果 有机和功能性 BA 对实足年龄的贡献几乎相同。在随机人群的二维系统中，有机和功能性 BA 都随着实际年龄的增长而增加。二维系统中糖尿病组与对照组分布有显着差异（p < 0.05）。糖尿病的第二象限多而第四象限少，这表明糖尿病对其他危险因素比对衰老更敏感。