OBJECTIVE Half of all newly diagnosed patients with glioblastoma are > 65 years still with a poor prognosis. Preserving quality of life is of high importance. However, patient reported outcome (PRO) data in this patient group is rare. The aim was to compare health-related quality of life (HRQoL) and distress between elderly and younger patients with high-grade glioma (HGG). METHODS We used baseline data of a prospective study where HGG patients were enrolled from 4 hospitals. Distress was measured using the distress thermometer (DT), HRQoL using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) plus brain module (BN20). We compared distress and HRQoL by age (≥ 65 vs. < 65 years), gender, performance score, and time since diagnosis using multivariate linear and logistic regressions. RESULTS A total of n = 93 (30%) out of n = 309 patients were ≥ 65 years (mean 70 years, range 65-86 years). Mean DT score of elderly patients (5.2, SD 2.6) was comparable with younger patients (4.9, SD 2.6). Elderly patients reported significantly lower global health (GHS, mean elderly vs. younger; 50.8 vs. 60.5, p = 0.003), worse physical (56.8 vs. 73.3, p < 0.001) and lower cognitive functioning (51.1 vs. 63.2, p = 0.002), worse fatigue (52.5 vs. 43.5, p = 0.042), and worse motor dysfunction (34.9 vs. 23.6, p = 0.030). KPS and not age was consistently associated with HRQoL. CONCLUSION Physical functioning was significantly reduced in the elderly compared with younger HGG patients, and at the same time, emotional functioning and DT scores were comparable. KPS shows a greater association with HRQoL than with calendric age in HGG patients reflecting the particular importance for adequate assessment of HRQoL and general condition in elderly patients.

中文翻译：

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一项多中心研究结果显示，老年和年轻高级别神经胶质瘤患者的健康相关生活质量和痛苦。

目的在所有新诊断的胶质母细胞瘤患者中，有一半以上> 65岁的患者预后仍然很差。保持生活质量至关重要。但是，此患者组中患者报告的结局（PRO）数据很少。目的是比较老年和年轻高级别神经胶质瘤（HGG）患者的健康相关生活质量（HRQoL）和困扰。方法我们使用了一项前瞻性研究的基线数据，该研究从4家医院入选了HGG患者。使用遇险温度计（DT），HRQoL使用欧洲癌症研究和治疗组织（EORTC）生活质量核心问卷（QLQ-C30）加上脑模块（BN20）来测量遇险情况。我们按年龄（≥65岁与<65岁），性别，表现得分，诊断以来的时间和时间，使用多元线性和逻辑回归。结果n 309名患者中，共有n = 93（30％）≥65岁（平均70岁，范围65-86岁）。老年患者的平均DT评分（5.2，SD 2.6）与年轻患者（4.9，SD 2.6）相当。老年患者报告的整体健康状况显着降低（GHS，平均老年vs.年轻; 50.8 vs. 60.5，p = 0.003），身体状况较差（56.8 vs. 73.3，p <0.001）和认知功能降低（51.1 vs. 63.2，p = 0.002），更差的疲劳感（52.5 vs.43.5，p = 0.042）和更严重的运动功能障碍（34.9 vs. 23.6，p = 0.030）。KPS而非年龄始终与HRQoL相关。结论与年轻的HGG患者相比，老年人的身体功能显着降低，同时，情绪功能和DT得分可比。