OBJECTIVE Half of all newly diagnosed patients with glioblastoma are > 65 years still with a poor prognosis. Preserving quality of life is of high importance. However, patient reported outcome (PRO) data in this patient group is rare. The aim was to compare health-related quality of life (HRQoL) and distress between elderly and younger patients with high-grade glioma (HGG). METHODS We used baseline data of a prospective study where HGG patients were enrolled from 4 hospitals. Distress was measured using the distress thermometer (DT), HRQoL using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) plus brain module (BN20). We compared distress and HRQoL by age (≥ 65 vs. < 65 years), gender, performance score, and time since diagnosis using multivariate linear and logistic regressions. RESULTS A total of n = 93 (30%) out of n = 309 patients were ≥ 65 years (mean 70 years, range 65-86 years). Mean DT score of elderly patients (5.2, SD 2.6) was comparable with younger patients (4.9, SD 2.6). Elderly patients reported significantly lower global health (GHS, mean elderly vs. younger; 50.8 vs. 60.5, p = 0.003), worse physical (56.8 vs. 73.3, p < 0.001) and lower cognitive functioning (51.1 vs. 63.2, p = 0.002), worse fatigue (52.5 vs. 43.5, p = 0.042), and worse motor dysfunction (34.9 vs. 23.6, p = 0.030). KPS and not age was consistently associated with HRQoL. CONCLUSION Physical functioning was significantly reduced in the elderly compared with younger HGG patients, and at the same time, emotional functioning and DT scores were comparable. KPS shows a greater association with HRQoL than with calendric age in HGG patients reflecting the particular importance for adequate assessment of HRQoL and general condition in elderly patients.

中文翻译：

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老年高级别胶质瘤患者与年轻患者的健康相关生活质量和痛苦——一项多中心研究的结果。


目的 所有新诊断的胶质母细胞瘤患者中有一半年龄 > 65 岁，预后仍较差。保持生活质量非常重要。然而，该患者组中患者报告的结果 (PRO) 数据很少。目的是比较老年和年轻高级别胶质瘤 (HGG) 患者的健康相关生活质量 (HRQoL) 和痛苦。方法 我们使用了一项前瞻性研究的基线数据，该研究招募了来自 4 家医院的 HGG 患者。使用痛苦温度计 (DT) 测量痛苦，使用欧洲癌症研究和治疗组织 (EORTC) 生活质量核心问卷 (QLQ-C30) 加上大脑模块 (BN20) 测量 HRQoL。我们使用多元线性和逻辑回归按年龄（≥ 65 岁与 < 65 岁）、性别、表现评分和诊断后时间比较痛苦和 HRQoL。结果 309 名患者中，共有 93 名 (30%) 患者年龄≥ 65 岁（平均 70 岁，范围 65-86 岁）。老年患者的平均 DT 评分（5.2，SD 2.6）与年轻患者的平均 DT 评分（4.9，SD 2.6）相当。老年患者的总体健康状况显着较低（GHS，平均老年人与年轻人；50.8 vs. 60.5，p = 0.003），身体状况较差（56.8 vs. 73.3，p < 0.001），认知功能较低（51.1 vs. 63.2，p = 0.001）。 0.002），更严重的疲劳（52.5 vs. 43.5，p = 0.042），以及更严重的运动功能障碍（34.9 vs. 23.6，p = 0.030）。 KPS 而不是年龄始终与 HRQoL 相关。结论 与年轻 HGG 患者相比，老年人的身体功能显着下降，同时情绪功能和 DT 评分具有可比性。 在 HGG 患者中，KPS 显示与 HRQoL 的相关性大于与日历年龄的相关性，这反映了对老年患者的 HRQoL 和一般状况进行充分评估的特别重要性。