The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.

中文翻译：

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对合作创始人菌株进行全面和比较的表型分析，确定了新的和已知的表型。


协作杂交 (CC) 是源自八个创始品系（NOD/ShiLtJ、NZO/HILtJ、A/J、C57BL/6J、129S1/SvImJ、CAST/EiJ、PWK/PhJ 和WSB/EiJ）。在这里，我们进行了全面的比较表型筛选，以确定八个创始菌株之间的表型差异和相似之处。总共分析了300多个参数，包括过敏、行为、心血管、临床血液化学、畸形、骨和软骨、能量代谢、眼睛和视力、免疫学、肺功能、神经学、伤害感受和病理学；十六名女性和十六名男性的大部分特征。我们确定了 270 多个参数，这些参数在菌株之间存在显着差异。这项研究强调了创始人菌株和 CC 菌株对于与人类疾病高度相关的许多遗传性状的表型-基因型关联的价值。这里描述的所有数据均可从小鼠表型数据库公开获取，以供分析和下载。