The intracellular localization of mRNAs allows neurons to control gene expression in neurite extensions (axons and dendrites) and respond rapidly to local stimuli. This plays an important role in diverse processes including neuronal growth and synaptic plasticity, which in turn serves as a foundation for learning and memory. Recent high-throughput analyses have revealed that neurites contain hundreds to thousands of mRNAs, but an analysis comparing the transcriptomes derived from these studies has been lacking. Here we analyze 20 datasets pertaining to neuronal mRNA localization across species and neuronal types and identify a conserved set of mRNAs that had robustly localized to neurites in a high number of the studies. The set includes mRNAs encoding for ribosomal proteins and other components of the translation machinery, mitochondrial proteins, cytoskeletal components, and proteins associated with neurite formation. Our combinatorial analysis provides a unique resource for future hypothesis-driven research. This article is categorized under: RNA Export and Localization > RNA Localization RNA Evolution and Genomics > Computational Analyses of RNA RNA Methods > RNA Analyses in Cells.

中文翻译：

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保护跨神经元类型和物种的核心神经突转录组。

mRNA 的细胞内定位允许神经元控制神经突延伸（轴突和树突）中的基因表达，并对局部刺激做出快速反应。这在包括神经元生长和突触可塑性在内的各种过程中起着重要作用，而突触可塑性又是学习和记忆的基础。最近的高通量分析表明，神经突包含数百到数千个 mRNA，但缺乏比较这些研究中转录组的分析。在这里，我们分析了与跨物种和神经元类型的神经元 mRNA 定位有关的 20 个数据集，并确定了一组保守的 mRNA，这些 mRNA 在大量研究中稳健地定位于神经突。该组包括编码核糖体蛋白和翻译机制的其他成分、线粒体蛋白、细胞骨架成分和与神经突形成相关的蛋白质。我们的组合分析为未来的假设驱动研究提供了独特的资源。本文分类如下：RNA 导出和定位 > RNA 定位 RNA 进化和基因组学 > RNA RNA 方法的计算分析 > 细胞中的 RNA 分析。