Rapid absorption of wound exudate and prevention of wound infection are prerequisites for wound dressing to accelerate wound healing. In this study, a novel kind of promising wound dressing is developed by incorporating polyhexamethylene guanidine (PHMG)‐modified graphene oxide (mGO) into the poly(vinyl alcohol)/chitosan (PVA/CS) matrix, conferring the dressing the required mechanical properties, higher water vapor transmission rate (WVTR), less swelling time, improved antibacterial activity, and more cell proliferation compared to the PVA/CS film crosslinked by genipin. In vivo experiments indicate that the PVA/CS/mGO composite film can accelerate wound healing via enhancement of the re‐epithelialization. PVA/CS/mGO composite film with 0.5 wt% mGO sheets displays the best wound healing properties, as manifested by the 50% higher antibacterial rate compared to GO and the wound healing rate of the mouse using this dressing is about 41% faster than the control group and 31% faster than the pure PVA/CS dressing. The underlying mechanism of the accelerated wound healing properties may be a result of the improved antibacterial ability to eradicate pathogenic bacteria on the wound area and maintain an appropriate moist aseptic wound healing environment to accelerate re‐epithelialization. These findings suggest that this novel composite PVA/CS/mGO film may have promising applications in wound dressing.

中文翻译：

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用于伤口敷料的新型聚乙烯醇/壳聚糖/氧化石墨烯生物复合材料。

伤口渗出液的快速吸收和伤口感染的预防是伤口敷料加速伤口愈合的先决条件。在这项研究中，通过将聚六亚甲基胍（PHMG）改性的氧化石墨烯（mGO）掺入聚乙烯醇/壳聚糖（PVA / CS）基质中，开发了一种新颖的有创伤口敷料，赋予敷料所需的机械性能，与通过Genipin交联的PVA / CS膜相比，具有更高的水蒸气透过率（WVTR），更少的溶胀时间，改善的抗菌活性以及更多的细胞增殖。体内实验表明，PVA / CS / mGO复合膜可通过增强上皮再生来加速伤口愈合。具有0.5 wt％mGO片的PVA / CS / mGO复合膜显示出最佳的伤口愈合性能，与GO相比，其抗菌率高出50％，而使用该敷料的小鼠的伤口愈合率比对照组快41％，比纯PVA / CS敷料快31％。加速伤口愈合特性的潜在机制可能是由于提高了抗菌能力，可以在伤口区域根除病原细菌并保持适当的潮湿无菌伤口愈合环境，从而加速上皮再生。这些发现表明，这种新颖的复合PVA / CS / mGO膜在伤口敷料中可能具有广阔的应用前景。加速伤口愈合特性的潜在机制可能是由于提高了抗菌能力，可以在伤口区域根除病原细菌并保持适当的潮湿无菌伤口愈合环境，从而加速上皮再生。这些发现表明，这种新颖的复合PVA / CS / mGO膜在伤口敷料中可能具有广阔的应用前景。加速伤口愈合特性的潜在机制可能是由于提高了抗菌能力，可以在伤口区域根除病原细菌并保持适当的潮湿无菌伤口愈合环境，从而加速上皮再生。这些发现表明，这种新颖的复合PVA / CS / mGO膜在伤口敷料中可能具有广阔的应用前景。